Download or read book A Comparison of the Antimicrobial Efficacy of Silver Diamine Fluoride and Silver Nitrate written by Nicholas L. Luke and published by . This book was released on 2018 with total page 27 pages. Available in PDF, EPUB and Kindle. Book excerpt: Purpose: To determine the antimicrobial efficacy of SDF and SN/NaF. Methods: Three bacterial species were combined to create an in vitro biofilm. Treatment was completed with SN, SN/NaF, SDF, SDF1⁄2 or untreated (control). Results: The untreated group demonstrated significantly higher growth than all other treatment groups across the study. On the BHI-plates (1-day), there were significant differences between all treatments except SDF and SDF1⁄2. On the BHI-plates (3-days), SN/NaF was not significantly different from SDF or SDF1⁄2. On the L-MRS-plates (1-day), both SN treatment groups yielded significantly higher growth than the SDF groups. On the L-MRS-plates (3-days), SN yielded significantly higher growth than SN/NaF, SDF, and SDF1⁄2. Conclusion: SDF is more effective than SN/NaF, with the exception of BHI-plates (3-days) only and SN/NaF is more effective than SN on primarily S. mutans and L. acidophilus. There is evidence of a possible antimicrobial tolerance of oral bacteria to silver.
Download or read book A Comparison of the Antimicrobial Efficacy of Silver Diamine Fluoride and Silver Nitrate on Various Cariogenic Bacteria written by Reham AlNajjar and published by . This book was released on 2019 with total page 23 pages. Available in PDF, EPUB and Kindle. Book excerpt: Purpose: The use of silver-based antimicrobials is an emerging method for the treatment of dental caries. In this study, the authors compare the efficacy of the two most prominent silver- based therapeutics, silver diamine fluoride (SDF) and silver nitrate (AgNO3), on cariogenic and non-cariogenic multispecies biofilms. Currently there is a lack of studies comparing the efficacy of SDF to AgNO3. Methods: Plaque samples from anterior and posterior tooth sites from children presenting both with early childhood caries and caries-free children were collected, pooled, and utilized to create four ex vivo biofilm systems in artificial saliva. SDF and AgNO3 were administered to these biofilms and bacterial survival was quantified and compared to untreated controls. Results: Each of the four pooled sample types was applied to plates coated in artificial saliva + 1% sucrose. Both SDF and AgNO3 were very effective against plaque derived biofilms when compared to untreated biofilms (P0.05) in the potency of each compound. Conclusions: SDF and AgNO3 significantly inhibit ex vivo cariogenic and non-cariogenic biofilms at similar levels.
Download or read book ANTIMICROBIAL EFFECTS IN VITRO OF SILVER DIAMINE FLUORIDE AGAINST SELECTED HUMAN RED AND ORANGE COMPLEX PERIODONTAL PATHOGENS written by Guillermo Jose Ramirez-Martinez and published by . This book was released on 2019 with total page 35 pages. Available in PDF, EPUB and Kindle. Book excerpt: Objectives: Silver diamine fluoride is approved by the United States Food and Drug Administration for intraoral human treatment of tooth hypersensitivity, and it has also been employed world-wide as an emerging method to arrest tooth decay. A 38% silver diamine fluoride formulation, comprised of 25% silver, 5% fluoride, and 8% ammonia as a solvent, is commercially available in the United States. One of the main mechanisms underlying the dental caries arrest potential of silver diamine fluoride is the silver component, which exerts pronounced antimicrobial activity against cariogenic bacteria. Interestingly, studies initiated in the late 1990s demonstrated marked susceptibility of periodontal bacterial pathogens to silver nitrate. However, efforts to develop silver-based, slow-release biodegradable wafers for subgingival placement into periodontal pockets were not commercially successful. At present, no commercial products are available which employ silver ions to combat periodontal bacterial pathogens in periodontal disease treatment. It is not known whether the 38% silver diamine fluoride product commercially available in the United States possesses antimicrobial activity against periodontal bacterial pathogens, and potentially, have application in periodontal therapeutic regimens. As a result, the objective of this study was to test the in vitro antimicrobial effects of silver diamine fluoride on freshly-isolated red and orange complex periodontal pathogens from severe human periodontitis lesions. Methods: Paper point subgingival biofilm samples from 24 adults with severe periodontitis that were to be discarded after microbiological analysis at the Temple University School of Dentistry Oral Microbiology Testing Service Laboratory were secondarily employed in this study. Dilution aliquots from each subgingival specimen were mixed with either 38% or 19% silver diamine fluoride, inoculated onto enriched Brucella blood agar plates, and incubated anaerobically for 7 days at 37°C. Bacterial species growing subsequent to the silver diamine fluoride exposure were considered to be resistant to that concentration of silver diamine fluoride. Total viable counts in silver diamine fluoride-exposed subgingival specimens were quantitated, and established phenotypic criteria employed to identify the following red and orange complex periodontal pathogens: Porphyromonas gingivalis, Tannerella forsythia, Prevotella intermedia/nigrescens, Parvimonas micra, Campylobacter rectus, Fusobacterium nucleatum group species, and Streptococcus constellatus. Other cultivable isolates recovered from silver diamine fluoride-exposed subgingival specimens were identified using matrix-assisted laser desorption-ionization time-of-flight (MALDI-TOF) mass spectrometry and Bruker MALDI Biotyper analytic software. Subgingival sample dilution aliquots not exposed to silver diamine fluoride were similarly processed as controls for comparison with silver diamine fluoride-exposed specimens Paired t-tests compared mean total subgingival viable counts, and mean total subgingival proportions of the evaluated anaerobic red and orange complex periodontal pathogens per patient, between subgingival biofilm samples exposed and not exposed in vitro to 38% or 19% silver diamine fluoride, with a P-value of
Download or read book Silver in Healthcare written by Alan B. G. Lansdown and published by Royal Society of Chemistry. This book was released on 2010-05-07 with total page 275 pages. Available in PDF, EPUB and Kindle. Book excerpt: Silver in healthcare has many different facets and since the early concepts of microbiology of the 1880's, has been developed from usage in surgical clips, staples, foil wound dressings and surgical implants, to the widespread and clinically effective antiseptic wound dressings, sutures, catheters, bone and dental implants, and cardiovascular devices of today. From the dawn of human civilisation, silver has had a role of water purification and even now has a role in hospital water systems for control of MRSA and legionnaires disease. Biotechnological advances in recent years have extended the antimicrobial properties of silver into production of hygiene textiles and use in domestic products. Important advances have been made in understanding mechanisms of antimicrobial action of silver, the central importance of ionisation patterns in the presence of body fluids and secretion, and the genetical and molecular profiles of silver resistance. This publication is a comprehensive account of the history of silver in medicine, its clinical benefits and wide advantages as a broad spectrum antimicrobial agent. It is clear from the extensive array of publications in recognised and unofficial press, that many misconceptions and misleading conceptions have been perpetuated, leading to errors in evaluation of the safety of the metal in occupational, domestic and therapeutic situations. The book is unique in that it is the only comprehensive presentation of the toxicology of silver and it identifies the major misconceptions in the safety of silver and interpretation of argyria and argyrosis as central features of silver toxicity. In this book, Dr Lansdown reviews the literature from a clinical and experimental viewpoint, with the benefit of his many years research on silver and experience gained in working with clinicians, healthcare product manufacturers and microbiologists. There is also discussion in the book on the relevance of antimicrobial resistance to silver and deficiencies in present day clinical practice in not evaluating incidences of resistance on a routine basis. The subject matter is presented in a readable fashion and includes reference to use of the metal in such practices as acupuncture and treatment of tropical diseases as practised in some parts of the world, each of which is accompanied by special clinical risk. It is also a collation of current views on the use and efficacy of silver as a broad spectrum antibiotic. The chapters which deal specifically with toxicological aspects of silver in clinical, occupational and environmental issues are central to the book's value. The book is aimed at clinicians, research scientists and product manufacturers and will provide ideas for new research and academic endeavour. It is also essential reading for research students with an interest in metal toxicity and its management in mammalian tissues.
Download or read book The Root Canal Biofilm written by Luis E. Chávez de Paz and published by Springer. This book was released on 2015-10-20 with total page 369 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the current state of research on the basic scientific aspects of root canal biofilm biology within a clinically applicable context. Root canal biofilms are complex polymicrobial structures adhering to the root canal surface that are formed by microorganisms invading the pulpal space of teeth, and are associated with persistent root canal infections. Concerted efforts to study root canal biofilms have been made in the past decade, resulting in the publication of observational and experimental studies that detail the morphology and biology of these structures in infected root canals. In addition to confirming that bacteria in root canals do not exist in free-floating planktonic states as previously assumed, this new information on root canal biofilm infections has provided an opportunity to re-evaluate conventional clinical protocols and improve endodontic therapeutic measures.
Download or read book Smart Nanodevices for Point of Care Applications written by Suvardhan Kanchi and published by CRC Press. This book was released on 2022-06-23 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Smart Nanodevices for Point-of-Care Applications examines the latest trends on the capabilities of nanomaterials for point-of-care (PoC) diagnostics and explains how these materials can help to strengthen, miniaturize, and improve the quality of diagnostic devices. A thorough explanation of all-in-one nanosmart devices is included, incorporating all of the applications and fundamentals of these smart devices. This book provides practical information on the following: novel and effective smart materials, better-quality health management, effective management of a disease, potential point-of-care devices, and mobile nanosensors. Additional Features Includes in-depth research based collation of the latest trends of smart devices Provides practical information on all-in-one nanosmart devices Explains how nanomaterials can help to strengthen and improve the quality of diagnostic devices Emphasizes the development of smart nanodevices, especially the miniaturization aspect
Download or read book Comparison of Antimicrobial Efficacy of Nanocrystalline Silver and Electoless Plated Silver on MRSA and P Aerugina written by Peter M. Ebeid and published by . This book was released on 2012 with total page 120 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Actions of Silver Diamine Fluoride on Dentine Caries and Its Caries Preventive Effect with Laser Irradiation written by Leticia Ito and published by . This book was released on 2017-01-26 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Actions of Silver Diamine Fluoride on Dentine Caries and Its Caries Preventive Effect With Laser Irradiation" by Leticia, Ito, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: The effect of silver diamine fluoride (SDF) on the mineral content of carious dentine and the preventive caries effect of erbium-doped yttrium aluminium garnet (Er: YAG) laser irradiation (2,940 nm) combined with SDF application under cariogenic biofilm challenge model was investigated. Firstly, the SDF mechanism of action in the remineralisation of demineralised dentine process observing changes in the mineral content in vitro was investigated. Secondly, we investigated the effect of various laser irradiations at sub-ablative energy levels on the fluoride uptake of 38% SDF treated dentine. Finally, we evaluated the effects of Er: YAG laser irradiation combined with SDF application on the fluoride uptake by dentine under a cariogenic biofilm challenge. Compared with a 10% sodium fluoride and potassium fluoride solution and a 42% silver nitrate solution with the same content of fluoride and silver respectively, 38% SDF is more effective in promoting remineralisation of demineralised dentine. The dentine samples treated with SDF did not show evident demineralised surface morphology. Although the lesion depth for SDF treated samples was not significantly deeper than for sodium fluoride treated samples, it was demonstrated that SDF has an inhibitory effect on dentine demineralization. The results of the SDF-laser experiment showed that carbon dioxide (CO2) laser irradiation (10,600 nm) followed by Er: YAG laser irradiation at specific sublablative levels promoted the higher fluoride uptake from SDF application than neodymium-doped yttrium aluminium garnet(Nd: YAG) laser (1,064 nm) and diode laser (810 nm) irradiation. This study provides guidelines for the selection of the appropriate laser irradiation parameters and types to promote an optimal level of fluoride uptake for dentine caries prevention. Er: YAG laser irradiation was elected among the laser types in the previous experiment for promoting higher levels of fluoride uptake and for its maximal absorption by water and high absorption by hydroxyapatite. The Er: YAG SDF-laser treated dentine was subjected cariogenic bacterial challenge to investigate the caries preventive effect of this treatment. The morphological surface of the treated samples presented many occluded dentinal tubules. There was a major increase in the hardness and elastic moduli values and the fluoride content also increased significantly after the remineralisation process. To conclude, this study demonstrated that SDF application inhibited dentine demineralization and arrested caries, and that SDF application followed by Er: YAG laser irradiation promoted an increase in fluoride uptake by sound dentine under a cariogenic biofilm challenge. Subjects: Fluorides - Therapeutic use Dental caries - Prevention
Download or read book Effectiveness of Silver Diamine Fluoride and Sodium Fluoride Varnish in Arresting Dentine Caries written by Chun-Hung Chu and published by . This book was released on 2017-01-27 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: This dissertation, "Effectiveness of Silver Diamine Fluoride and Sodium Fluoride Varnish in Arresting Dentine Caries" by Chun-hung, Chu, 朱振雄, was obtained from The University of Hong Kong (Pokfulam, Hong Kong) and is being sold pursuant to Creative Commons: Attribution 3.0 Hong Kong License. The content of this dissertation has not been altered in any way. We have altered the formatting in order to facilitate the ease of printing and reading of the dissertation. All rights not granted by the above license are retained by the author. Abstract: Abstract of thesis entitled Effectiveness of silver diamine fluoride and sodium fluoride varnish in arresting dentine caries submitted by Chu Chun Hung for the degree of Doctor of Philosophy at the University of Hong Kong in May 2004 Introduction: Caries prevalence in young children in China is high and most of the decayed teeth are left untreated. Conventional dental treatments are either not available or are unaffordable in many rural areas. Innovative approaches are needed to improve this situation. Aim: This prospective clinical trial investigated the effectiveness of topical fluoride applications in arresting dentine caries. The first null hypothesis to be tested was that there were no differences in the effectiveness of applying a 38% silver diamine fluoride (SDF) solution (44,800 ppm F), a 5% sodium fluoride (NaF) varnish (22,600 ppm F) and water in arresting dentine caries. The second null hypothesis was that caries removal prior to fluoride application had no impact on its effectiveness in arresting dentine caries. Methods: A total of 375 Chinese kindergarten children, aged 3-5 years with carious upper anterior teeth were divided into five groups. Children in the first and second groups received annual applications of SDF. NaF was applied every three months onto the lesions of children in the third and fourth groups. For children in the first and third groups, soft carious tissues were removed with hand instruments prior to fluoride application at the baseline examination. The fifth group of children received annual applications of water. Follow-up examinations were performed every six months. The children's parents completed a questionnaire to assess parental satisfaction with the appearance of the upper anterior teeth of their child before treatment and again at 24 months after treatment. Results: A total of 308 children were followed for 30 months. The respective mean numbers of arrested caries tooth surfaces in the five groups of children were 2.5, 2.8, 1.5, 1.5 and 1.3 (pDOI: 10.5353/th_b3016250 Subjects: Dental caries - Prevention Dental caries in children Fluorides - Therapeutic use Sodium fluoride - Therapeutic use
Download or read book Geriatric Dentistry written by Paula K. Friedman and published by John Wiley & Sons. This book was released on 2014-07-30 with total page 624 pages. Available in PDF, EPUB and Kindle. Book excerpt: Geriatric Dentistry: Caring for Our Aging Population provides general practitioners, dental students, and auxiliary members of the dental team with a comprehensive, practical guide to oral healthcare for the aging population. Beginning with fundamental chapters on the psychological, environmental, and social aspects of aging, the book approaches patient care from a holistic point of view. Subsequent chapters show the importance of this information in a practical context by discussing how it affects office environment, decision?-making and treatment planning, and the management and treatment of common geriatric oral conditions. Case studies and study questions are used to illustrate application of educational presentations to practice settings. Contributed by leaders in the field, Geriatric Dentistry will strengthen readers’ understanding and clinical acumen in addressing this special population.
Download or read book The Effectiveness of Silver Diamine Fluoride when Used to Arrest Caries in Children and Associated Oral Health related Quality of Life written by Rena Sihra and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Objective: To investigate the efficacy of silver diamine fluoride (SDF) with 5% fluoride varnish (FV) in treating cavitated caries in young children and to explore the association between SDF treatment and oral health-related quality of life (OHRQoL). Methods: Children with active dentinal caries lesions (ICDAS 5 or 6) in primary teeth underwent treatment with 38% SDF and 5% FV at baseline and 4 months later. Treated lesions were assessed 4 and 8 months after baseline to determine arrest. Participants were deemed Completely Successful (CS) if all treated lesions were arrested and Incompletely Successful (IS) if at least one lesion was not arrested. The early childhood oral health impact scale (ECOHIS) questionnaire was completed at second and third visits. Statistical analyses included descriptive and bivariate methods. A P value ≤ 0.05 was significant. Results: Forty children with 239 caries lesions were enrolled; mean age 40.2 +/- 14.9 months and 45% male. Lesion arrest rates after one and two applications of SDF were 74.1% and 96.2%, respectively. Children who reportedly brushed twice daily were more likely to be in the CS group compared to those who brushed less (p=0.006). Participants in the CS group had a significantly lower mean baseline dmft score than those in the IS group (p= 0.048). No significant difference in OHRQoL was observed between CS and IS groups. Conclusions: SDF with 5% FV is an effective approach to the management of ECC; more than one application is recommended along with regular follow-up of patients and twice daily brushing. OHRQoL was not found to be affected by the level of success of SDF treatment.
Download or read book Pediatric Restorative Dentistry written by Soraya Coelho Leal and published by Springer. This book was released on 2018-09-11 with total page 227 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book describes and discusses the different restorative options for managing carious lesions in children with primary and mixed dentition. The aim is to provide practitioners with thorough, up-to-date information that will improve their clinical practice. The opening chapters present a comprehensive overview regarding diagnosis of carious lesions, risk assessment, child behavior and development, and behavioral management. The importance of oral health promotion and prevention in controlling lesion progression and maintaining oral health is reviewed. The impact of various factors on clinician decision making is then explained in detail, examples including the type of dentition (primary versus permanent), the clinical and radiographic aspect of the dentine carious lesion (noncavitated or cavitated), and whether the lesion is associated with a developmental defect. Guidance is provided on selection of nonoperative versus operative interventions, and the restorative materials most frequently used in pediatric dentistry are fully described, highlighting their advantages and disadvantages. Readers will also find an informative series of cases, with explanation of the choices in terms of materials and approach.
Download or read book The Delivery of Nanoparticles written by Abbass A. Hashim and published by BoD – Books on Demand. This book was released on 2012-05-16 with total page 556 pages. Available in PDF, EPUB and Kindle. Book excerpt: Nanoparticle is a general challenge for today's technology and the near future observations of science. Nanoparticles cover mostly all types of sciences and manufacturing technologies. The properties of this particle are flying over today scientific barriers and have passed the limitations of conventional sciences. This is the reason why nanoparticles have been evaluated for the use in many fields. InTech publisher and the contributing authors of this book in nanoparticles are all overconfident to invite all scientists to read this new book. The book's potential was held until it was approached by the art of exploring the most advanced research in the field of nano-scale particles, preparation techniques and the way of reaching their destination. 25 reputable chapters were framed in this book and there were alienated into four altered sections; Toxic Nanoparticles, Drug Nanoparticles, Biological Activities and Nano-Technology.
Download or read book Microbicides for the Protection of Materials written by W. Paulus and published by Springer Science & Business Media. This book was released on 1993-09-30 with total page 526 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is chiefly intended for those who are using microbicides for the protection of materials. Another purpose is to inform teachers and students working on biodeterioration and to show today's technical standard to those engaged in R&D activities in the microbicide field. When trying to classify, or to subclassify, material-protecting microbicides according to their mode of action, e.g. as membrane-active and electrophilic active ingredients, it turned out that a clear assignment was not always possible. For that reason the author has resorted to chemistry's principle of classifying according to groups of substances (e.g. alcohols, aldehydes, ketones, acids, esters, amides, etc.), thus providing the first necessary information about the micro bicides' properties. The description of the various groups of substances includes, whenever possible, an outline of the mode and mechanism of action of the active ingredients involved. The effective use of microbicides presupposes knowledge of their character istics. That is why the microbicides' chemico-physical properties, their toxicity, ecotoxicity, effectiveness, and effective spectrum are described in greater detail. As mentioned before, the characteristics of microbicides play an important role. They have to be suited to the intended application to avoid detrimental effects on the properties and the quality of the material to be protected; also production processes in which microbicides are used to avoid disturbances by microbial action must not be disturbed by the presence of those microbicides.
Download or read book Biological Activities and Application of Marine Polysaccharides written by Emad Shalaby and published by BoD – Books on Demand. This book was released on 2017-01-11 with total page 330 pages. Available in PDF, EPUB and Kindle. Book excerpt: Marine organisms have been under research for the last decades as a source for different active compounds with various biological activities and application in agriculture, pharmacy, medicine, environment, and industries. Marine polysaccharides from these active compounds are used as antibacterial, antiviral, antioxidant, anti-inflammation, bioremediations, etc. During the last three decades, several important factors that control the production of phytoplankton polysaccharides have been identified such as chemical concentrations, temperature, light, etc. The current book includes 14 chapters contributed by experts around the world; the chapters are categorized into three sections: Marine Polysaccharides and Agriculture, Marine Polysaccharides and Biological Activities, and Marine Polysaccharides and Industries.
Download or read book An Atlas of Glass Ionomer Cements written by Graham J. Mount and published by Thieme. This book was released on 2002 with total page 222 pages. Available in PDF, EPUB and Kindle. Book excerpt: This comprehensive clinical guide to the uses of glass-ionomers in operative dentistry has been updated throughout.
Download or read book Artificial Metalloenzymes and MetalloDNAzymes in Catalysis written by Montserrat Diéguez and published by John Wiley & Sons. This book was released on 2018-02-21 with total page 431 pages. Available in PDF, EPUB and Kindle. Book excerpt: An important reference for researchers in the field of metal-enzyme hybrid catalysis Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a comprehensive review of the most current strategies, developed over recent decades, for the design, synthesis, and optimization of these hybrid catalysts as well as material about their application. The contributors—noted experts in the field—present information on the preparation, characterization, and optimization of artificial metalloenzymes in a timely and authoritative manner. The authors present a thorough examination of this interesting new platform for catalysis that combines the excellent selective recognition/binding properties of enzymes with transition metal catalysts. The text includes information on the various applications of metal-enzyme hybrid catalysts for novel reactions, offers insights into the latest advances in the field, and contains an informative perspective on the future: Explores the development of artificial metalloenzymes, the modern and strongly evolving research field on the verge of industrial application Contains a comprehensive reference to the research area of metal-enzyme hybrid catalysis that has experienced tremendous growth in recent years Includes contributions from leading researchers in the field Shows how this new catalysis combines the selective recognition/binding properties of enzymes with transition metal catalysts Written for catalytic chemists, bioinorganic chemists, biochemists, and organic chemists, Artificial Metalloenzymes and MetalloDNAzymes in Catalysis offers a unique reference to the fundamentals, concepts, applications, and the most recent developments for more efficient and sustainable synthesis.
