Download or read book A Comparison of Phase Transition Properties of Supported Phospholipid Mono and Bilayers written by Sennur Turgut and published by . This book was released on 2008 with total page 98 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Phase and Phase transition Properties of Mono and Diglyceride Lipid Bilayers Investigated Using Molecular Dynamics Simulations written by Monika Laner and published by . This book was released on 2014 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book LIPIDAT A Database of Thermo Data and Association Information on Lipid written by Martin Caffrey and published by CRC Press. This book was released on 1993-06-04 with total page 334 pages. Available in PDF, EPUB and Kindle. Book excerpt: LIPIDAT is a convenient compilation of thermodynamic data and bibliographic information on lipids. Over 11,000 records in 15 information fields are provided. The book presents tabulations of all known mesomorphic and polymorphic phase transition types, temperatures, and enthalpies for synthetic and biologically derived lipids in dry, partially hydrated, and fully hydrated states. It also includes the effect of pH, protein, drugs, salt, and metal ion concentration on these thermodynamic values. Methods used in making the measurements and the experimental conditions are reported. Bibliographic information includes a complete literature reference and list of authors. The book will be an indispensable reference for biophysicists, chemical engineers, pharmaceutical and cosmetic researchers, dermatologists, nutritionists, biochemists, physiologists, food scientists, and fats and oils chemists.
Download or read book Phase Transitions Hydration and Spreading of Phospholipid Bilayers and Monolayers at the Air water Interface written by Heidi M. Mansour and published by . This book was released on 2003 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Interactions of Disruptive Materials with Phospholipid Bilayers written by Andrew S. Campbell and published by . This book was released on 2011 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: The eukaryotic cell membrane is a complex mixture of cholesterol, lipids, and proteins. Direct study of the cell membrane must include these multiple variables, which significantly complicates their analysis. Model systems minimize the number of components used in a membrane study. Atomic force microscopy (AFM) can be employed to study the morphology of model supported phospholipid bilayers (SLB). Thermal and diffusive properties of membranes are identified using differential scanning calorimetry (DSC) and fluorescence correlation spectroscopy (FCS). Attenuated total reflectance infrared spectroscopy (ATR-FTIR) can be applied to observe SLB disruption. This suite of techniques has been used to observe interactions of molecules interfering with phospholipid bilayers. Single- and multicomponent SLBs and phospholipid vesicles are employed as models of cell membranes. The effects of the pore-forming peptide alamethicin are shown for lipid bilayers with varying compositions. A correlation between the presence of sphingomyelin or cholesterol and increased pore formation is identified by the increase of potassium leakage through vesicles and formation of raft structures visible with AFM. ATR-FTIR shows that alamethicin disrupts all types of bilayers studied, suggesting that the observed effects are directly correlated to alamethicin incorporation. A comparison is made between the interactions of two polychlorinated biphenyl isomers and an SLB. A study of AFM micrographs identifies multiple phase transitions in one isomer, but only one phase transition for the other isomer. Two transitions are consistent with an uninterrupted bilayer, but one transition suggests that an intercalated molecule ties the bilayer leaflets together, or a contaminant molecule disrupts substrate ordering on the bilayer. DSC results show that one isomer is more strongly associated with the bilayer than the other isomer, a difference that is explained based on geometric differences in the isomers. FCS is employed to observe a PCB-lipid complex which highlights the different strengths of interaction between PCB isomers and lipids. A model is proposed where the ortho-substituted PCB isomer inserts into the bilayer and strongly associates with the hydrophobic region. In contrast, the planar PCB isomer does not insert deeply past the hydrophilic region of the bilayer, which allows it to interrupt interactions between the substrate and its closest bilayer leaflet. We employ atomic force microscopy to show interactions of sphingomyelin or cholesterol with a mixed DSPC/DOTAP bilayer. We report that sphingomyelin, but not cholesterol, supports the formation of hexagonal crystalline domains. These domains are small (ca. 70 nm) and can be observed with AFM as high as 40°C. We use differential scanning calorimetry of DSPC/DOTAP vesicles in the presence of either sphingomyelin or gramicidin A to show the elimination of one thermogram peak. This result suggests that sphingomyelin, like gramicidin A, interacts with both leaflets in the bilayer. We report dichroic ratios measured from each bilayer composition with ATR-FTIR. The methylene dichroic ratios in all bilayers decrease with introduction of both SM and Chol, but the magnitude of decrease is greater in the presence of SM. A decrease in methylene dichroic ratios is related to an increase in lipid chain order. We propose that SM exerts extensive hydrogen-bonding forces on DSPC and sustains structure to high temperatures when incorporated in a 40 mol% ratio. At this same temperature, we propose that Chol does not support the same structure formation because it induces the liquid-ordered phase in DSPC/DOTAP. We note that sphingomyelin promotes multilayer, not bilayer, formation.
Download or read book Cumulated Index Medicus written by and published by . This book was released on 1989 with total page 1422 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Planar Lipid Bilayers and Liposomes written by and published by Elsevier. This book was released on 2014-07-18 with total page 238 pages. Available in PDF, EPUB and Kindle. Book excerpt: Although the origin and the basic meaning of the terms "planar lipid bilayers" and "liposome" have not changed during the years, the present advances in the scientific, technological, biomedical and consumer product fields are remarkable. Ever since its launch the "Advances in Planar Lipid Bilayers and Liposomes’ (APLBL) has provided a global platform for a community of researchers having very broad scientific interests in theoretical, experimental and simulation studies on lipid and cell membrane micro and nanostructures. Ranging from artificial lipid membranes to cell membranes, controlled release of functional molecules, drug delivery to cancer cells, pharmaceutical formulations to food products, the applications are simply enormous. An assortment of chapters in APLBL represents both an original research as well as comprehensives reviews written by world leading experts and young researchers. Gives a survey on recent theoretical as well as experimental results on lipid micro and nanonanostructures In addition, the potential use of the basic knowledge in applications like clinically relevant diagnostic and therapeutic procedures, biotechnology, pharmaceutical engineering and food products is presented
Download or read book Structural Behavior of Free Versus Supported Ternary Lipid Bilayer Membranes written by Holden Timothy Ranz and published by . This book was released on 2015 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: Ternary lipid bilayer systems assembled from mixtures of dipalmitoylphosphatidylcholine (DPPC), dioleoylphosphatidylcholine (DOPC), and cholesterol have been studied using coarse-grained molecular dynamics at biologically relevant temperatures (280 K to 310 K), which fall between the chain melting temperatures of each pure lipid component. Free lipid bilayers were simulated using the MARTINI model (Stage I) and a variant with water-water interactions reduced to 76% (Stage II). The latter was subsequently used for preparing supported lipid bilayer simulations (Stage III). Clustering of like lipids was observed, but the simulation timescale did not yield larger phase-separated domains as expected for many systems. However, several critical phase transitions were elucidated by comparing static and dynamic bilayer properties. Such properties include bilayer thicknesses, lateral diffusion coefficients of head groups, and lipid chain order parameters. Bilayer thickness fell within the expected range of liquid/gel phase behavior, and order parameters had semi-quantitative agreement with NMR experiments. Diffusion coefficients had some qualitative agreement with data from pfg-NMR measurements when scaled up by a factor of 10. A solid support generally induced ordering within the bilayer, but at 310 K the inner-water region was often comprised of ordered layers and disordered particles, resulting in non-planar bilayer conformations.
Download or read book Near field Investigations of the Anisotropic Properties of Supported Lipid Bilayers written by Merrell A. Johnson and published by . This book was released on 2011 with total page 382 pages. Available in PDF, EPUB and Kindle. Book excerpt: The details of Polarization Modulation Near-Field Scanning Optical Microscopy (PM-NSOM) are presented. How to properly calibrate and align the system is also introduced. A measurement of Muscovite crystal is used to display the capabilities of the setup. Measurements of supported Lβʹ 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) lipid bilayers are presented, emphasizing how it was tooled in exploiting the anisotropic nature of the acyl chains. A discussion of how the effective retardance (ΔS = 2π(n_e-n_o)t/λ) and the direction of the projection of the acyl chains (θ) are measured simultaneously is given, (where t is the thickness of the bilayer and λ is the wavelength of light used). It is shown from ΔS the birefringence (ne-no) of the bilayer is determined, by assuming the acyl chain tilt with respect to the membrane's normal to be [phi] ≈ 32°. Time varying experiments show lateral diffusions of ~ 2 x 10-12 cm2/s. Temperature controlled PM-NSOM is shown to be a viable way to determine the main phase transition temperature (Tm) for going from the gel Lβʹ to liquid disorder Lα state of supported DPPC bilayers. A change of ΔS ~ .٨ +/- ٠.٣ فٍْل) ف ٰوٰم فٍى َوِفٱم فْٰٱَىىٰ َُمٰمٍِفْ�ٰمْ ش ٍ(́٤١℗ʻ أ) ىٱ قُٱم�ْمل. شوىٱ فهمْمٱ �م ٌٌ�ىوٰ مِْ�ى�ُٱ �ف�ٌمٱ نُ (مَ-)َُ فلَ فْٰٱَفٌمٰٱ ُٰف َفٱٱ�مٍل [وِى] � ٣٢℗ʻ �وم َش ش ٍفلَ ٠℗ʻ �وم َش ش.ٍ إ�ىلمكَم نُ ٱ�مِِ ْومفىٰهَ فلَ ٱ�مِِ ْكىٌُُهَ �ى ٌٌقم مِْٱممَٰل، فهٌَُ �ىوٰ ف لىٱك�ٱٱى َُنُ وٰم ن�ٌك�ٰفىٰٱَُ وٰف ٰكُك� ْف�ُْلَ ش.ٍ ئىفَ”ٌٌ ى ٰىٱ ٱو�ُ َو�ُ وِ”ٱىكف ٌفِفْمٍمٰٱْ ٱ�كو فٱ وٰم فٌُِىْ“فقىىٌ”ٰ فمْ م٬فْٰكمٰل ن ٍُْوٰم لففٰ. ضف�ٌمٱ نُ وٰم فْٰٱَ�مٱْم (�ł)ٰ فلَ هٌَُى�ٰلىفَ ٌ(�ł)ٌ فٌُِىْ“فقىىٌمٰٱ نُ وٰم فك” ٌكوفىٱَ فمْ ٱو�ُ َ ُٰقم، �ł ٰ= ٤٤.٢ © ٣ فلَ �ł ٌ= ٩٤.٤ © ٣، �وىكو كمُْْٱلَُِ �م ٌٌ�ىوٰ وٰم وٰممُْىٰكف ٌ�ف�ٌمٱ نُ ف ٱىهَمٌ فِىٌٍىٰك فكىل (أ١٦) �ł ٰ= ٢٥.١٤ © ٣ فلَ �ł ٌ= ٤٥.٨ © ٣.
Download or read book Phospholipid Bilayers written by Gregor Cevc and published by Wiley-Interscience. This book was released on 1987-05-04 with total page 472 pages. Available in PDF, EPUB and Kindle. Book excerpt: Introduces the principles underlying the fundamental physical properties of phospholipid bilayer membranes and summarizes current research in the field and directions for research. Covers the various methods of approach, summarizes a range of specific models, and gives detailed accounts of those models most useful for future work. Introduces the subject in a way that is accessible to those with little background in the subject, while presenting information at the forefront of current knowledge concerning it.
Download or read book Publications of the National Institute of Standards and Technology Catalog written by National Institute of Standards and Technology (U.S.) and published by . This book was released on 1994 with total page 1162 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Artificial Kidney Bibliography written by and published by . This book was released on 1972 with total page 580 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Kidney Disease and Nephrology Index written by and published by . This book was released on 1975-07 with total page 816 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Encyclopedia of Surface and Colloid Science written by P. Somasundaran and published by CRC Press. This book was released on 2006 with total page 1152 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Advances in Planar Lipid Bilayers and Liposomes written by A. Leitmannova Liu and published by Elsevier. This book was released on 2011-09-21 with total page 337 pages. Available in PDF, EPUB and Kindle. Book excerpt: The lipid bilayer is central to life, as all living organisms possess a lipid bilayer structure, thereby underlying the lipid bilayer principle of biomembranes. The lipid bilayer principle and its applications are the main theme of this new book series.This new series on bilayer lipid membranes (BLMs and liposomes) include invited chapters on a broad range of topics, from theoretical investigations, specific studies, experimental methods, to practical applications. Written for newcomers, experienced scientists, and those who are not familiar with these specific research areas, the Series covers all aspects of lipid bilayer investigations, both fundamental and applied. * Covers a broad range of topics ranging from theoretical research, specific studies, experimental methods, to practical applications* Authoritative timely reviews by experts in this field* Indispensable source of information for new scientists
Download or read book Trends in Colloid and Interface Science V written by M. Corti and published by Springer. This book was released on 2007-12-11 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Physics Briefs written by and published by . This book was released on 1992 with total page 812 pages. Available in PDF, EPUB and Kindle. Book excerpt:
