Download or read book Crafting Immunity written by Kenton Kroker and published by Ashgate Publishing, Ltd.. This book was released on 2008 with total page 326 pages. Available in PDF, EPUB and Kindle. Book excerpt: Immunity is as old as illness itself, yet historians have only just begun to take up the challenge of reconstructing the modern transformation of attempts to protect against disease. Crafting Immunity assembles in one volume the most recent efforts of an international group of scholars to place the diverse practices of immunity in their historical contexts. It is this diversity that provides the book with its greatest source of strength. Collectively, the papers in this volume suggest that it was the craft-like, small-scale, and local conditions of clinical medicine that turned the immunity of individuals and populations into biomedical objects. That is to say, the modern conception of immunity was at least as much the product of the work of healing as it was the systematic result of discoveries about the immune system.Working outside the narrow confines of laboratory histories, Crafting Immunity is the first attempt to set the problems of immunity into a variety of social, technological, institutional and intellectual contexts. It will appeal not only to historians and sociologists of health, but also to social and cultural historians interested in the biomedical creation of modern health regimens.

Download or read book Animal Genomics for Animal Health written by Marie-Hélène Pinard and published by Karger Medical and Scientific Publishers. This book was released on 2008-01-01 with total page 455 pages. Available in PDF, EPUB and Kindle. Book excerpt: "It includes a review of the state of the art in animal genomics and its applications to animal health. The contributions describe the new tools available, such as HapMaps for chicken and cattle, and show how the understanding of gene structure and function can be successfully applied to delineate the molecular mechanisms of disease and determine complex phenotypes associated with health traits. A critical evaluation of future needs and future applications of animal genomics is also presented. The integration of animal genomics in animal health research is likely to revolutionize the way scientists approach the challenges of discovering highly effective drugs and vaccines for animal diseases."--BOOK JACKET.

Download or read book Physico chemical Procedures for the Characterization of Vaccines written by Fred Brown and published by S. Karger AG (Switzerland). This book was released on 2000 with total page 296 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This volume contains contributions describing the application of all the principal methods currently in use for evaluating carbohydrate, lipopolysaccharide, lipid, protein, glycoprotein, and lipoprotein components of vaccines, whether produced by conventional methods or recombinant technology. It is clear from the information presented that this approach is gaining momentum and that we are seeing only the beginning of its impact in the field of vaccines and vaccinology."--BOOK JACKET.

Download or read book DNA Vaccines written by Hildegund C. J. Ertl and published by Springer Science & Business Media. This book was released on 2003 with total page 374 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA Vaccines: An Introduction; M.R. Hilleman. Architecture of a DNA vaccine; G. Pavlakis. DNA vaccine delivery; S. Kaufmann. Adjuvanticity of DNA vaccines; A. Krieg. Immune responses to DNA vaccines: Antigen presentation; R. Steinman. Immune responses to DNA vaccines: Antigen processing; J. Yewdell. Immune responses to DNA vaccines: Induction of B cells; G. Kelsoe. Immune responses to DNA vaccines: Induction of CD4+ T cells; E. Shevach. Immune responses to DNA vaccines: Induction of CD8+ T cells; L. Whitton. Immune responses to DNA vaccines: Cytokines as immune mediators as part of the immune response and their potential as genetic adjuvants to DNA vaccines; H. Ertl. Immune responses to DNA vaccines: Chemokines as immune mediators as part of the immune response and their potential as genetic adjuvants to DNA vaccines; P. Murphy. DNA Vaccines to infectious agents: RNA viruses; J. Ulmer. DNA Vaccines to infectious agents: HIV/SIV; B. Wahren. DNA Vaccines to infectious agents: DNA viruses; B. Rouse. DNA Vaccines to infectious agents: Tumor-associated viruses (excluding HBV); R. Kennedy. DNA Vaccines to infectious agents: Bacteria; D. Lowrie. DNA Vaccines to infectious agents: Parasites; S. Hoffman. Use of DNA vaccines for neonatal/early childhood immunization; C.-A. Siegrist. The potential of DNA vaccines for developing countries; H. Wilde. DNA vaccines and their potential to counterbalance biological warfare/bioterrorism; A. Schmaljohn. DNA vaccines to cancer associated/specific antigens; DNA vaccines to autoimmune diseases; H. Wigzell. DNA vaccines to allergic diseases; Yan Chuah, P. Holt. DNA vaccines for gene therapy; K. High. Safety concerns for DNA; D. Klinman. DNA vaccines: Summary.

Download or read book Vaccines and Diagnostics for Transboundary Animal Diseases written by J.A. Roth and published by Karger Medical and Scientific Publishers. This book was released on 2013-04-18 with total page 231 pages. Available in PDF, EPUB and Kindle. Book excerpt: Transboundary animal diseases (TADs) are a major threat to livestock. They are highly contagious or transmissible, and they have the potential to cause high morbidity and mortality in both susceptible animal populations and humans. In addition, not only are TADs detrimental to national economies, they are also a serious threat to world food security. This volume presents the proceedings of an international workshop on Vaccines and Diagnostics for Transboundary Animal Diseases that was held in Ames (Iowa, USA) in 2012. Experts and scientists from academia, industry and government reviewed the current status of vaccines and diagnostics for high priority TADs, decision-making and regulatory processes for veterinary biologics, and the roles and responsibilities of government agencies. The discussions also addressed achievements and gaps in vaccine and diagnostics development for 11 important TADs as well as the translation of research findings into licensed novel vaccines and diagnostics for high-priority TADs.

Download or read book The Oxford Handbook of the Cold War written by Richard H. Immerman and published by Oxford University Press, USA. This book was released on 2013-01-31 with total page 681 pages. Available in PDF, EPUB and Kindle. Book excerpt: The Oxford Handbook of the Cold War offers a broad reassessment of the period war based on new conceptual frameworks developed in the field of international history. Nearing the 25th anniversary of its end, the cold war now emerges as a distinct period in twentieth-century history, yet one which should be evaluated within the broader context of global political, economic, social, and cultural developments. The editors have brought together leading scholars in cold war history to offer a new assessment of the state of the field and identify fundamental questions for future research. The individual chapters in this volume evaluate both the extent and the limits of the cold war's reach in world history. They call into question orthodox ways of ordering the chronology of the cold war and also present new insights into the global dimension of the conflict. Even though each essay offers a unique perspective, together they show the interconnectedness between cold war and national and transnational developments, including long-standing conflicts that preceded the cold war and persisted after its end, or global transformations in areas such as human rights or economic and cultural globalization. Because of its broad mandate, the volume is structured not along conventional chronological lines, but thematically, offering essays on conceptual frameworks, regional perspectives, cold war instruments and cold war challenges. The result is a rich and diverse accounting of the ways in which the cold war should be positioned within the broader context of world history.

Download or read book OIE FAO International Scientific Conference on Avian Influenza written by Alejandro Schudel and published by S. Karger AG (Switzerland). This book was released on 2006 with total page 292 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph comprises the proceedings of the International Conference on Avian Influenza held in Paris, France, in April 2005. Discussed were new scientific discoveries in the domain of avian influenza (AI), with special emphasis on the highly pathogenic avian influenza (HPAI). It provides important up-to-date information on the virology, epidemiology and molecular biology as well as the history of episodes of avian influenza in different parts of the world and their consequences. The publication aims at making recommendations to compare and improve the international procedures and standards related to the identification, prevention, control and elimination of AI epizootics as they are a threat to the livelihood of farmers, especially in developing countries, to public health as well as to national economies. Chief veterinary officers, animal health regulatory officials, veterinarians, poultry-raising associations, consumer associations, specialised journalists and all those who need to understand and control AI episodes will benefit from reading this book.

Download or read book Development and Clinical Progress of DNA Vaccines written by Fred Brown and published by S. Karger AG (Switzerland). This book was released on 2000 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: DNA vaccines have progressed rapidly from the conceptual stage to the stage of clinical trials. While studies in small laboratory animals have shown great promise, initial reports from human studies were less encouraging. Progress is being made, however, documented by the papers presented here. This volume contains the proceedings of a meeting devoted to the latest developments in DNA vaccines, from laboratory studies to clinical trials. The papers, written by leaders in the field, focus on the current state of DNA vaccines in humans and other large animals. The bulk of the studies involve DNA vaccines against HIV/SIV. Other promising trials make use of DNA vaccines against malaria and hepatitis B. The papers inform the reader about the immune basis of this form of vaccination and about approaches being developed to increase the efficacy of DNA vaccines in humans. These include the co-administration of cytokines, prime-boost strategies, optimising codon usage or the use of CpG motifs. An excellent up-to-the-minute account, this volume should be read by anyone in academia or in industry involved in DNA vaccination. The book will also be of great interest to clinicians involved in trials and those in the regulatory area.

Download or read book Advancing Science and Elimination of the Use of Laboratory Animals for the Development and Control of Vaccines and Hormones written by Fred Brown and published by S. Karger AG (Switzerland). This book was released on 2002 with total page 360 pages. Available in PDF, EPUB and Kindle. Book excerpt: Animal experimentation plays a major role in the development and control of biological products and large numbers of animals are used for routine batch control. During the past few years considerable attention has been paid to the concept of replacing, reducing and refining (the three Rs) the use of animals for this purpose. This volume contains the proceedings of an international meeting held in Utrecht in November 2001 in which the problems associated with applying the three Rs were discussed. Particular emphasis was given to the validation and regulatory acceptance of in vitro methods and new concepts of quality control. Those issues are important for the scientific community at large as well as manufacturers, regulatory authorities and everyone concerned with animal welfare.

Download or read book Biologics 2000 written by Fred Brown and published by S. Karger AG (Switzerland). This book was released on 2002 with total page 172 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reviews current scientific developments and regulatory issues relating to establishing comparability of biological products when manufactured within a single company or jointly with other companies.

Download or read book First International Conference of the OIE Reference Laboratories and Collaborating Centres Florianopolis Brazil 3 5 December 2006 written by Michel Lombard and published by S. Karger AG (Switzerland). This book was released on 2007 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: The 'OIE Global Network' of Reference Laboratories and Collaborating Centres is a key resource for the early and accurate diagnosis of animal disease pathogens and information pertaining to them. It provides expert support with the supply of science-based international reagents as well as the development of standards and guidelines for animal welfare and the food safety aspects of animal production, and recommendations for the prevention, detection and control of diseases such as zoonoses. The first international meeting of experts from 'OIE Reference Laboratories and Collaborating Centres' addressed the updating and setting of standards for methodologies in the fields of diagnostics, vaccine quality and biosecurity; the improvement of methods for internet networking, and the building of closer links between existing Reference Laboratories, Collaborating Centres and national and private veterinary laboratories. It demonstrated the need for OIE institutions to support developing and in-transition countries in facing current challenges and new threats linked to globalization and climate change through twinning, capacity building, and training programs.

Download or read book State of the Art Analytical Methods for the Characterization of Biological Products and Assessment of Comparability written by Anthony R. Mire-Sluis and published by S. Karger AG (Switzerland). This book was released on 2005 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt: With the latest advances in analytical technologies, most biological products can now be extensively characterized in terms of their identity, heterogeneity and impurity profile. The currently available analytical methods (both physicochemical and biological) can characterize the primary, secondary and to some extent, the higher order structure of proteins. The sensitivity and selectivity of these methods allow for the identification and characterization not only of the desired protein component, but also many product-related substances and impurities as well as process-related impurities present in the drug preparations. Using an appropriate selection of analytical tools, it may be possible to demonstrate physicochemical and functional comparability between protein products manufactured before and after a manufacturing change or during product development. However, the extent of demonstrable comparability depends on the tests used, on the nature of the product and on the basic understanding of structure-function relationships. Assessment of immunogenicity is also a critical component of product characterization and is highly dependent on the types of assays used.

Download or read book The OIE Global Conference on Aquatic Animal Health Bergen Norway 9 12 October 2006 written by Betty Dodet and published by S. Karger AG (Switzerland). This book was released on 2007 with total page 208 pages. Available in PDF, EPUB and Kindle. Book excerpt: Aquaculture is one of the fastest growing industries globally; its production volume currently represents over 40% of all fisheries and within a few years will surpass that of traditional fisheries. New species and methodologies contribute to the fact that new emerging diseases are increasingly being discovered within this field, and aquatic animal welfare issues are only just beginning to be considered. This OIE Global Conference on Aquatic Animal Health was an opportunity for the OIE and its Member Countries to help build a framework for improved involvement and cooperation between the authorities (Veterinary and Fish Health, Fisheries and Environment), the scientific community and the private sector on aquatic animal health and welfare; help clarify the roles and responsibilities of all stakeholders in the process of early disease detection, rapid response and reporting; help increase aquatic animal health emergency response capabilities; exchange information on emerging diseases and animal welfare issues; help develop a science-based approach to the management of aquatic animal health and welfare; and present the valuable experience gained in the past few years. Following the presentations and discussions, recommendations were developed to better define roles and responsibilities and to assist in the evaluation and improvement of the current standards and guidelines for better control of infectious aquatic animal health, and the preparedness of countries for aquatic animal disease emergencies.

Download or read book Laboratory Correlates of Immunity to Influenza written by Fred Brown and published by . This book was released on 2003 with total page 184 pages. Available in PDF, EPUB and Kindle. Book excerpt: For some 30 years it has been a rule of thumb that antibody to influenza haemagglutinin, induced by natural infection or vaccination, is a universal and useful marker of immunity to influenza. It now seems important to re-examine this hypothesis. Knowledge of the mechanisms of acquired influenza immunity and correlations with measurable laboratory parameters is clearly of importance in understanding influenza epidemiology and vaccine-induced immunity. While immunity is certainly multi-factorial, involving both B and T cell responses, any comprehensive assessment is complicated by the capacity of the virus to undergo extensive and frequent antigenic variation. The aim of this workshop was to review the methods available for assessing immune responses and their advantages and disadvantages; to present information on immune responses to the various vaccine types and attempt to draw possible conclusions on their value in assessing protective immunity; to address the question of standardization and validation of assays and the appropriate use of reference materials; to identify appropriate themes for international collaborative studies.

Download or read book Development of Therapeutic Cancer Vaccines written by Fred Brown and published by S. Karger AG (Switzerland). This book was released on 2004 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: This monograph contains the proceedings of a conference devoted to progress and emerging issues in therapeutic cancer vaccine development since the 1998 FDA/NCI workshop. The emphasis is on progress in the clinical trials of cancer vaccines in late-stage development, but the volume also includes presentations and discussions on exciting earlier-stage products as well as updates on regulatory positions in the USA, Canada, Europe, and Australia. Session I concentrates on regulatory considerations in cancer vaccine development, including a round table of regulatory agency representatives from North America, Europe, and Australia. Session II continues with a consideration of several different types of cancer vaccines, including whole cells, cell lysates, multivalent recombinants and peptides. Session III highlights dendritic cell vaccines and dendritic cells fused to tumour cell vaccines. Session IV focuses on preventive cancer vaccines for cervical carcinoma and liver cancer and various aspects of the immune response to cancer vaccines.

Download or read book Process Validation for Manufacturing of Biologics and Biotechnology Products written by Fred Brown and published by S. Karger AG (Switzerland). This book was released on 2003 with total page 148 pages. Available in PDF, EPUB and Kindle. Book excerpt: Attempting to fill the gap Regulatory documents and inspections have put increasing emphasis on process validation for all types of products, including biological and biotechnological ones. Until now, no description of a process validation for complex biological processes exists, let alone any concrete suggestion how to attain it: this book, however, attempts to fill the gap. Taking the current state of scientific practice in process validation as a starting point, this volume portrays the expectations of the regulatory community and provides detailed examples of how various types of biological and biotechnological processes could be validated. Considering the sizeable difficulties in designing a single method of process validation suitable for all types of processes and products, the authors discuss the implications and present many possible routes to a successful validation process.

Download or read book Progress in Fish Vaccinology written by Paul J. Midtlyng and published by S. Karger AG (Switzerland). This book was released on 2005 with total page 356 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This volume gives a comprehensive update on recent developments in fish vaccinology and the potential and current use of vaccines in modern fish farming. The book will be an indispensable aid and source of up-to-date information for fish health professionals, managers in the aquaculture industry, and industrial researchers working in the field of fish immunology, vaccine development and disease control world-wide." --Book Jacket.