Download or read book A Beginners Guide to Systems Simulation in Immunology written by Grazziela Figueredo and published by . This book was released on 2016 with total page 14 pages. Available in PDF, EPUB and Kindle. Book excerpt: Some common systems modelling and simulation approaches for immune problems are Monte Carlo simulations, system dynamics, discrete-event simulation and agent-based simulation. These methods, however, are still not widely adopted in immunology research. In addition, to our knowledge, there is few research on the processes for the development of simulation models for the immune system. Hence, for this work, we have two contributions to knowledge. The first one is to show the importance of systems simulation to help immunological research and to draw the attention of simulation developers to this research field. The second contribution is the introduction of a quick guide containing the main steps for modelling and simulation in immunology, together with challenges that occur during the model development. Further, this paper introduces an example of a simulation problem, where we test our guidelines.
Download or read book Systems Immunology written by Jayajit Das and published by CRC Press. This book was released on 2018-09-03 with total page 442 pages. Available in PDF, EPUB and Kindle. Book excerpt: "Taken together, the body of information contained in this book provides readers with a bird’s-eye view of different aspects of exciting work at the convergence of disciplines that will ultimately lead to a future where we understand how immunity is regulated, and how we can harness this knowledge toward practical ends that reduce human suffering. I commend the editors for putting this volume together." –Arup K. Chakraborty, Robert T. Haslam Professor of Chemical Engineering, and Professor of Physics, Chemistry, and Biological Engineering, Massachusetts Institute of Technology, Cambridge, USA New experimental techniques in immunology have produced large and complex data sets that require quantitative modeling for analysis. This book provides a complete overview of computational immunology, from basic concepts to mathematical modeling at the single molecule, cellular, organism, and population levels. It showcases modern mechanistic models and their use in making predictions, designing experiments, and elucidating underlying biochemical processes. It begins with an introduction to data analysis, approximations, and assumptions used in model building. Core chapters address models and methods for studying immune responses, with fundamental concepts clearly defined. Readers from immunology, quantitative biology, and applied physics will benefit from the following: Fundamental principles of computational immunology and modern quantitative methods for studying immune response at the single molecule, cellular, organism, and population levels. An overview of basic concepts in modeling and data analysis. Coverage of topics where mechanistic modeling has contributed substantially to current understanding. Discussion of genetic diversity of the immune system, cell signaling in the immune system, immune response at the cell population scale, and ecology of host-pathogen interactions.
Download or read book Artificial Immune Systems written by Carlos A. Coello-Coello and published by Springer. This book was released on 2012-08-27 with total page 309 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book constitutes the refereed proceedings of the 11th International Conference on Artificial Immune Systems, ICARIS 2012, held in Taormia, Italy, in August 2012. The 19 revised selected papers presented were carefully reviewed and selected for inclusion in this book. In addition 4 papers of the workshop on bio and immune inspired algorithms and models for multi-level complex systems are included in this volume. Artificial immune systems (AIS) is a diverse and maturing area of research that bridges the disciplines of immunology, biology, medical science, computer science, physics, mathematics and engineering. The scope of AIS ranges from modelling and simulation of the immune system through to immune-inspired algorithms and in silico, in vitro and in vivo solutions.
Download or read book Immune System Modelling and Simulation written by Filippo Castiglione and published by CRC Press. This book was released on 2015-04-07 with total page 284 pages. Available in PDF, EPUB and Kindle. Book excerpt: The book describes a computational model of the immune system reaction, C-ImmSim, built along the lines of the computer model known as the Celada-Seiden model (CS-model). The computational counterpart of the CS-model is called IMMSIM which stands for IMMune system SIMulator. IMMSIM was written in 1992 by the physicist Phil E. Seiden and the immunol
Download or read book Immune system modeling and analysis written by Ramit Mehr and published by Frontiers Media SA. This book was released on 2015-04-22 with total page 402 pages. Available in PDF, EPUB and Kindle. Book excerpt: The rapid development of new methods for immunological data collection – from multicolor flow cytometry, through single-cell imaging, to deep sequencing – presents us now, for the first time, with the ability to analyze and compare large amounts of immunological data in health, aging and disease. The exponential growth of these datasets, however, challenges the theoretical immunology community to develop methods for data organization and analysis. Furthermore, the need to test hypotheses regarding immune function, and generate predictions regarding the outcomes of medical interventions, necessitates the development of mathematical and computational models covering processes on multiple scales, from the genetic and molecular to the cellular and system scales. The last few decades have seen the development of methods for presentation and analysis of clonal repertoires (those of T and B lymphocytes) and phenotypic (surface-marker based) repertoires of all lymphocyte types, and for modeling the intricate network of molecular and cellular interactions within the immune systems. This e-Book, which has first appeared as a ‘Frontiers in Immunology’ research topic, provides a comprehensive, online, open access snapshot of the current state of the art on immune system modeling and analysis.
Download or read book Mathematical Modeling of the Immune System in Homeostasis Infection and Disease written by Gennady Bocharov and published by Frontiers Media SA. This book was released on 2020-02-24 with total page 278 pages. Available in PDF, EPUB and Kindle. Book excerpt: The immune system provides the host organism with defense mechanisms against invading pathogens and tumor development and it plays an active role in tissue and organ regeneration. Deviations from the normal physiological functioning of the immune system can lead to the development of diseases with various pathologies including autoimmune diseases and cancer. Modern research in immunology is characterized by an unprecedented level of detail that has progressed towards viewing the immune system as numerous components that function together as a whole network. Currently, we are facing significant difficulties in analyzing the data being generated from high-throughput technologies for understanding immune system dynamics and functions, a problem known as the ‘curse of dimensionality’. As the mainstream research in mathematical immunology is based on low-resolution models, a fundamental question is how complex the mathematical models should be? To respond to this challenging issue, we advocate a hypothesis-driven approach to formulate and apply available mathematical modelling technologies for understanding the complexity of the immune system. Moreover, pure empirical analyses of immune system behavior and the system’s response to external perturbations can only produce a static description of the individual components of the immune system and the interactions between them. Shifting our view of the immune system from a static schematic perception to a dynamic multi-level system is a daunting task. It requires the development of appropriate mathematical methodologies for the holistic and quantitative analysis of multi-level molecular and cellular networks. Their coordinated behavior is dynamically controlled via distributed feedback and feedforward mechanisms which altogether orchestrate immune system functions. The molecular regulatory loops inherent to the immune system that mediate cellular behaviors, e.g. exhaustion, suppression, activation and tuning, can be analyzed using mathematical categories such as multi-stability, switches, ultra-sensitivity, distributed system, graph dynamics, or hierarchical control. GB is supported by the Russian Science Foundation (grant 18-11-00171). AM is also supported by grants from the Spanish Ministry of Economy, Industry and Competitiveness and FEDER grant no. SAF2016-75505-R, the “María de Maeztu” Programme for Units of Excellence in R&D (MDM-2014-0370) and the Russian Science Foundation (grant 18-11-00171).
Download or read book Conceptual Modelling in Computational Immunology written by Martina Husáková and published by Tomáš Bruckner. This book was released on 2015-09-10 with total page 174 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational immunology offers in silico strategies for understanding of complex processes occurring in the natural immune system of a living organism that are difficult to explore by traditional in vivo or in vitro techniques. The monograph introduces conceptual languages and approaches for modelling biological processes. The Agent Modelling Language is investigated for conceptualisation of immune processes. AML-based diagrams represent properties and processes occurring in a lymph node.
Download or read book Computational Immunology written by Josep Bassaganya-Riera and published by Academic Press. This book was released on 2015-10-21 with total page 212 pages. Available in PDF, EPUB and Kindle. Book excerpt: Computational Immunology: Models and Tools encompasses the methodological framework and application of cutting-edge tools and techniques to study immunological processes at a systems level, along with the concept of multi-scale modeling. The book's emphasis is on selected cases studies and application of the most updated technologies in computational modeling, discussing topics such as computational modeling and its usage in immunological research, bioinformatics infrastructure, ODE based modeling, agent based modeling, and high performance computing, data analytics, and multiscale modeling. There are also modeling exercises using recent tools and models which lead the readers to a thorough comprehension and applicability. The book is a valuable resource for immunologists, computational biologists, bioinformaticians, biotechnologists, and computer scientists, as well as all those who wish to broaden their knowledge in systems modeling. - Offers case studies with different levels of complexity - Provides a detailed view on cutting-edge tools for modeling that are useful to experimentalists with limited computational skills - Explores the usage of simulation for hypothesis generation, helping the reader to understand the most valuable points on experimental setting
Download or read book Basic Immunology E Book written by Abul K. Abbas and published by Elsevier Health Sciences. This book was released on 2012-11-05 with total page 342 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understand all the essential concepts in immunology with Basic Immunology: Functions and Disorders of the Immune System! This concise, focused text provides you with an up-to-date, accessible introduction to the workings of the human immune system. Efficiently master the immunology information you need through clinically focused content, logically organized by mechanism. Apply what you've learned to real-world situations by referencing the appendix of clinical cases. Enhance your learning with the help of numerous full-color illustrations and useful tables, as well as summary boxes, review questions, and a glossary of immunology terms. Study immunology anywhere! Online access to www.StudentConsult.com opens the door to an enhanced e-book and ancillary components! Visualize complex immunology concepts with a completely updated art program. Test your knowledge. New PowerPoint Review slides added to www.StudentConsult.com are ideal for study sessions.
Download or read book How the Immune System Works written by Lauren M. Sompayrac and published by John Wiley & Sons. This book was released on 2011-12-02 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt: How the Immune System Works is not a comprehensive textbook. It’s the book thousands of students have used to help them understand what’s in their big, thick, immunology texts. In this book, Dr. Sompayrac cuts through the jargon and details to reveal, in simple language, the essence of this complex subject. Fifteen easy to follow lectures, featuring the uniquely popular humorous style and engaging analogies developed by Dr Sompayrac, provide an introduction to the ‘bigger picture’, followed by practical discussion on how each of the components interacts with one another. Now featuring full-color diagrams, this book has been rigorously updated for its fourth edition to reflect today’s immunology teaching and includes updated discussion of B and T cell memory, T cell activation, vaccines, immunodeficiency, and cancer. Whether you are completely new to immunology, or require a refresher, How the Immune System Works is an enjoyable way of engaging with the key concepts – you need know nothing of the workings of the immune system to benefit from this book! How the Immune System Works is now accompanied by a FREE enhanced Wiley Desktop Edition - the interactive, digital version of the book - featuring downloadable text and images, highlighting and note taking facilities, book-marking, cross-referencing, in-text searching, and linking to references and glossary terms. It is also available from CourseSmart for instant, online and offline access for studying anytime, anywhere.
Download or read book In Silico Immunology written by Darren D.R. Flower and published by Springer Science & Business Media. This book was released on 2007-04-16 with total page 453 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book outlines three emergent disciplines, which are now poised to engineer a paradigm shift from hypothesis- to data-driven research: theoretical immunology, immunoinformatics, and Artificial Immune Systems. It details how these disciplines will enable new understanding to emerge from the analysis of complex datasets. Coverage shows how these three are set to transform immunological science and the future of health care.
Download or read book Immunology for Beginners written by Massoud Abbas and published by Independently Published. This book was released on 2021-06-21 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the world of medicine, the term immunology is an expansive and complex field within the discipline of anatomy. This branch of the medical sciences focuses on how the body's immune system works and interacts with other systems. The immune system is a network of cells, tissues, and organs whose main purpose is to protect the body from foreign substances. This system protects the body from disease and infections. This field of medicine is also responsible for the development of vaccines that humans use to protect themselves from such diseases. During my time working in the immunology sphere, I have had the opportunity to interact with several patients who come to me with different complaints and symptoms that may be related to some kind of immunological abnormality. I have also had to deal with patients who may have been exposed to some kind of infectious agent that could put their health at risk. That is why having an understanding of immunology is important for the general population. It is for this reason that I have written this book in an easy-to- digest format so that you can have a better understanding of the concepts behind immune function and disease. This book is based on my research as a doctor and biologist focusing on immunology and it offers a general overview of the different topics that are related to this discipline. This book provides information about the basics of immunology, the immunity system, and ways to prevent sickness. Some of the topics that are covered in this book include the process of immune response, the different types of white blood cells, the different types of antibodies and how they work, and many others. My name is Massoud Abbas, and this book is my way of giving back to society by sharing knowledge that I acquired while working and studying in this field.
Download or read book Integrative Computational Systems Biology Approaches in Immunology and Medicine written by Lars Kaderali and published by Frontiers Media SA. This book was released on 2019-04-09 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book The Immune System written by Rodney E. Langman and published by . This book was released on 1989-01-01 with total page 209 pages. Available in PDF, EPUB and Kindle. Book excerpt: (5E 1991) Concer
Download or read book Statistical and Modelling Techniques to Build Confidence in the Investigation of Immunology Through Agent based Simulation written by and published by . This book was released on 2011 with total page 316 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book High Performance Programming for Soft Computing written by Oscar Humberto Montiel Ross and published by CRC Press. This book was released on 2014-02-04 with total page 371 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book examines the present and future of soft computer techniques. It explains how to use the latest technological tools, such as multicore processors and graphics processing units, to implement highly efficient intelligent system methods using a general purpose computer.
Download or read book IMMUNOINFORMATICS written by and published by . This book was released on 2020 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:
