Download or read book 99Tc Bioassay written by LA. Lewis and published by . This book was released on 1998 with total page 12 pages. Available in PDF, EPUB and Kindle. Book excerpt: A means of analyzing 99Tc in urine by inductively coupled plasma mass spectrometry (ICP-MS) has been developed. Historically, 99Tc analysis was based on the radiometric detection of the 293 keV Emax. beta decay product by liquid scintillation or gas flow proportional counting. A separation scheme for 99Tc detection by ICP-MS is given and is proven to be a sensitive and robust analytical alternative. A comparison of methods using radiometric and mass quantitation of 99Tc has been conducted in water, artificial urine, and real urine matrices at activity levels between 700 and 2200 dpm/L. Liquid scintillation results based on an external standard manual quench correction and an automatic quench curve correction method are compared with results obtained by ICP-MS. Each method produced accurate results; however, the precision of the ICP-MS results is superior to that of liquid scintillation results.
Download or read book 99Tc Bioassay by Inductively Coupled Plasma Mass Spectrometry ICP MS written by and published by . This book was released on 1998 with total page 129 pages. Available in PDF, EPUB and Kindle. Book excerpt: A means of analyzing 99Tc in urine by inductively coupled plasma mass spectrometry (ICP-MS) has been developed. Historically, 99Tc analysis was based on the radiometric detection of the 293 keV E{sub Max} beta decay product by liquid scintillation or gas flow proportional counting. In a urine matrix, the analysis of99Tc is plagued with many difficulties using conventional radiometric methods. Difficulties originate during chemical separation due to the volatile nature of Tc2O-- or during radiation detection due to color or chemical quenching. A separation scheme for 99Tc detection by ICP-MS is given and is proven to be a sensitive and robust analytical alternative. A comparison of methods using radiometric and mass quantitation of 99Tc has been conducted in water, artificial urine, and real urine matrices at activity levels between 700 and 2,200 dpm/L. Liquid scintillation results based on an external standard quench correction and a quench curve correction method are compared to results obtained by ICP-MS. Each method produced accurate results, however the precision of the ICP-MS results is superior to that of liquid scintillation results. Limits of detection (LOD) for ICP-MS and liquid scintillation detection are 14.67 and 203.4 dpm/L, respectively, in a real urine matrix. In order to determine the basis for the increased precision of the ICP-MS results, the detection sensitivity for each method is derived and measured. The detection sensitivity for the 99Tc isotope by ICP-MS is 2.175 x 10−7 " 8.990 x 10−9 and by liquid scintillation is 7.434 x 10−14 " 7.461 x 10−15. A difference by seven orders of magnitude between the two detection systems allows ICP-MS samples to be analyzed for a period of 15 s compared to 3,600 s by liquid scintillation counting with a lower LOD.
Download or read book 99Tc Bioassay by Inductively Coupled Plasma Mass Spectrometry ICP MS written by Linda A. Lewis and published by . This book was released on 1998 with total page 228 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Inductively Coupled Plasma Mass Spectrometry written by Howard E. Taylor and published by Academic Press. This book was released on 2001 with total page 320 pages. Available in PDF, EPUB and Kindle. Book excerpt: It also includes information on processing and interpreting results to obtain high-quality data.".
Download or read book Molybdenum 99 for Medical Imaging written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2016-11-28 with total page 264 pages. Available in PDF, EPUB and Kindle. Book excerpt: The decay product of the medical isotope molybdenum-99 (Mo-99), technetium-99m (Tc-99m), and associated medical isotopes iodine-131 (I-131) and xenon-133 (Xe-133) are used worldwide for medical diagnostic imaging or therapy. The United States consumes about half of the world's supply of Mo-99, but there has been no domestic (i.e., U.S.-based) production of this isotope since the late 1980s. The United States imports Mo-99 for domestic use from Australia, Canada, Europe, and South Africa. Mo-99 and Tc-99m cannot be stockpiled for use because of their short half-lives. Consequently, they must be routinely produced and delivered to medical imaging centers. Almost all Mo-99 for medical use is produced by irradiating highly enriched uranium (HEU) targets in research reactors, several of which are over 50 years old and are approaching the end of their operating lives. Unanticipated and extended shutdowns of some of these old reactors have resulted in severe Mo-99 supply shortages in the United States and other countries. Some of these shortages have disrupted the delivery of medical care. Molybdenum-99 for Medical Imaging examines the production and utilization of Mo-99 and associated medical isotopes, and provides recommendations for medical use.
Download or read book Medical Isotope Production Without Highly Enriched Uranium written by National Research Council and published by National Academies Press. This book was released on 2009-06-27 with total page 220 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book is the product of a congressionally mandated study to examine the feasibility of eliminating the use of highly enriched uranium (HEU2) in reactor fuel, reactor targets, and medical isotope production facilities. The book focuses primarily on the use of HEU for the production of the medical isotope molybdenum-99 (Mo-99), whose decay product, technetium-99m3 (Tc-99m), is used in the majority of medical diagnostic imaging procedures in the United States, and secondarily on the use of HEU for research and test reactor fuel. The supply of Mo-99 in the U.S. is likely to be unreliable until newer production sources come online. The reliability of the current supply system is an important medical isotope concern; this book concludes that achieving a cost difference of less than 10 percent in facilities that will need to convert from HEU- to LEU-based Mo-99 production is much less important than is reliability of supply.
Download or read book Applications of Inductively Coupled Plasma mass Spectrometry to Radionuclide Determinations written by Roy W. Morrow and published by ASTM International. This book was released on 1995 with total page 153 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Annual Book of ASTM Standards written by ASTM International and published by . This book was released on 2003 with total page 1196 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Opportunities and Approaches for Supplying Molybdenum 99 and Associated Medical Isotopes to Global Markets written by National Academies of Sciences, Engineering, and Medicine and published by National Academies Press. This book was released on 2018-03-12 with total page 87 pages. Available in PDF, EPUB and Kindle. Book excerpt: Participants of the July 17-18, 2017, symposium titled Opportunities and Approaches for Supplying Molybdenum-99 and Associated Medical Isotopes to Global Markets examined current trends in molybdenum-99 production, prospects for new global supplies, and technical, economic, regulatory, and other considerations for supplying molybdenum-99 to global markets. This publication summarizes the presentations and discussions from the symposium.
Download or read book Radioactivity Radiochemistry written by and published by . This book was released on 1998 with total page 434 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pesticides Documentation Bulletin written by and published by . This book was released on 1966 with total page 1274 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Energy Research Abstracts written by and published by . This book was released on 1995 with total page 782 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Fundamentals of Nuclear Pharmacy written by Gopal B. Saha and published by Springer. This book was released on 2017-11-11 with total page 430 pages. Available in PDF, EPUB and Kindle. Book excerpt: Currently an estimated 17 million nuclear medicine procedures are performed each year in the US and constantly evolving, as new radiopharmaceuticals and imaging techniques are introduced for better diagnosis and treatment of human diseases. In keeping up with new developments, the Seventh Edition of Fundamentals of Nuclear Pharmacy chronicles the advancements in radiopharmaceuticals and their use in clinical applications. It discusses basic concepts such as the atom, radioactive decay, instrumentation and production of radionuclides, and explores the design, labeling, characteristics and quality control of radiopharmaceuticals. Radiation regulations and diagnostic and therapeutic applications of radiopharmaceuticals are detailed. Thoroughly updated, the Seventh Edition includes new topics such as alternative productions of 99Mo; production of 64Cu, 86Y, 89Zr, 177Lu, 223Ra; synthesis and clinical uses of new radiopharmaceuticals such as DaTscan, Xofigo, Amyvid, Neuraceq, Vizamyl, Axumin and 68Ga-DOTATATE; dosimetry of new radiopharmaceuticals; theranostic agents and translational medicine. It features numerous examples, diagrams, and images to further clarify the information and offers end- of-chapter questions to help readers assess their comprehension of the material. Recognized as a classic text on nuclear chemistry and pharmacy and acclaimed for its concise and easy-to-understand presentation, Fundamentals of Nuclear Pharmacy is an authoritative resource for nuclear medicine physicians, residents, students, and technologists.
Download or read book Development of Kits for 99mTc Radiopharmaceuticals for Infection Imaging written by International Atomic Energy Agency and published by IAEA. This book was released on 2004 with total page 132 pages. Available in PDF, EPUB and Kindle. Book excerpt: Dated September 2004. Includes papers by various authors
Download or read book Inventory of Federal Energy related Environment and Safety Research for written by and published by . This book was released on 1980 with total page 704 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Handbook of Radioactivity Analysis written by Michael F. L'Annunziata and published by Academic Press. This book was released on 2012-09-01 with total page 1419 pages. Available in PDF, EPUB and Kindle. Book excerpt: The updated and much expanded 3e of the Handbook of Radioactivity Analysis is an authoritative reference providing the principles, practical techniques, and procedures for the accurate measurement of radioactivity from the very low levels encountered in the environment to higher levels measured in radioisotope research, clinical laboratories, biological sciences, radionuclide standardization, nuclear medicine, nuclear power, and fuel cycle facilities and in the implementation of nuclear forensic analysis and nuclear safeguards. The book describes the basic principles of radiation detection and measurement and the preparation of samples from a wide variety of matrices, assists the investigator or technician in the selection and use of appropriate radiation detectors, and presents state-of-the-art methods of analysis. Fundamentals of radiation properties, radionuclide decay, the calculations involved, and methods of detection provide the basis for a thorough understanding of the analytical procedures. The Handbook of Radioactivity Analysis, 3e, is suitable as a teaching text for university and professional training courses. - The only comprehensive reference that describes the principles of detection and practical applications of every type of radioactivity detector currently used. The new 3e is broader in scope, with revised and expanded chapters, new authors, and seven new chapters on Alpha Spectrometry, Radionuclide Standardization, Radioactive Aerosol Measurements, Environmental Radioactivity Monitoring, Marine Radioactivity Analysis, Nuclear Forensic Analysis and Analytical Techniques in Nuclear Safeguards - Discusses in detail the principles, theory and practice applied to all types of radiation detection and measurement, making it useful for both teaching and research
Download or read book Inventory of Federal Energy related Environment and Safety Research for FY 1978 Project listings and indexes written by and published by . This book was released on 1979 with total page 740 pages. Available in PDF, EPUB and Kindle. Book excerpt:
