Download or read book 44th Annual Meeting of the European Society for Dermatological Research written by and published by . This book was released on 2014 with total page 135 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book 15th Annual Meeting of the European Society for Dermatological Research written by European Society for Dermatological Research and published by . This book was released on 1985 with total page 68 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book 50th Annual Meeting of the European Society for Dermatological Research written by European Society for Dermatological Research and published by . This book was released on 2021 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book 47th Annual Meeting of the European Society for Dermatological Research written by European Society for Dermatological Research and published by . This book was released on 2017 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Annual European Society for Dermatological Research ESDR written by European Society for Dermatological Research and published by . This book was released on 1990 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book 49th Annual Meeting of the European Society for Dermatological Research written by European Society for Dermatological Research and published by . This book was released on 2019 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book PROGRAM AND ABSTRACTS 3RD ANNUAL MEETING EUROPEAN SOCIETY FOR DERMATOLOGICAL RESEARCH written by and published by . This book was released on with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Annual 35th European Society for Dermatological Research ESDR Meeting written by European Society for Dermatological Research and published by . This book was released on 2005 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Abstracts for the 26th Annual Meeting of the European Society for Dermatological Research written by European Society for Dermatological Research and published by . This book was released on 1996 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book 39th Annual Meeting of the European Society for Dermatological Research written by European Society for Dermatological Research and published by . This book was released on 2009 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book 40th Annual Meeting of the European Society for Dermatological Research written by European Society for Dermatological Research and published by . This book was released on 2010 with total page 121 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Biobetters written by Amy Rosenberg and published by Springer. This book was released on 2015-08-21 with total page 384 pages. Available in PDF, EPUB and Kindle. Book excerpt: “Biobetters: Protein Engineering to Approach the Curative” discusses the optimization of protein therapeutic products for treatment of human diseases. It is based on the fact that though numerous important therapeutic protein products have been developed for life threatening and chronic diseases that possess acceptable safety and efficacy profiles, these products have generally not been reexamined and modified for an improved clinical performance, with enhancements both to safety and efficacy profiles. Advances in protein engineering, coupled with greatly enhanced understanding of critical product quality attributes for efficacy and safety, make it possible to optimize predecessor products for clinical performance, thereby enhancing patient quality of life and with the potential for great savings in health care costs. Yet despite such knowledge, there is little movement towards such modifications. This book examines engineering protein therapeutic products such that they exhibit an optimal, not just an adequate, clinical performance profile. Two product classes, therapeutic enzymes for lysosomal storage diseases (enzyme replacement therapies, ERT) and monoclonal antibodies (mAbs), are used as examples of what modifications to such proteins could be made to enhance clinical performance, “closer to a cure” as it were. For ERT, the key to optimizing clinical performance is to ensure the ERT is endowed with moieties that target the protein to the relevant target tissue. Thus, for Gaucher Disease, our best example of how to optimize an ERT to address a disease that manifests in specific target tissues (macrophages and monocytes), the enzyme has been extensively modified to target macrophages. For diseases such as Pompe Disease, largely a disorder of muscle, optimal performance of ERT will depend on endowing the enzyme with the ability to be taken up via the Mannose 6 Phosphate Receptor, and so one of the chapters in the book will discuss such approaches. Moreover, a major failure of biotechnology based products is to gain access to the CNS, a key target tissue in numerous diseases. Thus, a chapter has been devoted to strategies to access the CNS. Additionally, immune responses to therapeutic proteins can be highly problematic, eliminating the efficacy of life saving or highly effective protein therapeutics. This is especially poignant in the case of Pompe Disease wherein great improvement in muscle strength and functionality is lost following development of an immune response to the ERT with consequent patient deterioration and death. Thus, a chapter regarding protein engineering, as well as other non-clinical approaches to diminishing immunogenicity is a valuable part of the book. Monoclonal antibodies (mAbs) can be engineered to bind targets relevant to a wide variety of diseases; binding affinity, however, is only part of the equation and one of the chapters will present a molecular assessment approach that balances affinity with pharmacokinetics and manufacturability. As with other proteins immunogenicity can be problematic, being responsible for loss of efficacy of anti-TNF mAbs, often after prolonged successful treatment. The authors will also share their perspective on the consequences of physico-chemical modifications occurring to mAbs once they reach the circulation or their target, a research area open to further development from a protein engineering as well as analytical perspective. This book will also discuss novel platforms for protein therapeutics, technologies that exceed mAbs with respect to potency, and hence, potentially efficacy. These platforms consist largely of repeat domain proteins with very high affinity for their target ligands, but while potentially more efficacious, immunogenicity may be a major problem limiting use. The economics surrounding the issue of biobetters is another high-profile issue - this final chapter will explore the incentives and disincentives for developing biobetters and consider incentives that might make their pursuit more rewarding.

Download or read book Skin Autoimmunity written by Ralf J. Ludwig and published by Frontiers Media SA. This book was released on 2021-05-25 with total page 754 pages. Available in PDF, EPUB and Kindle. Book excerpt:

Download or read book Environmental Health Perspectives written by and published by . This book was released on 2004 with total page 1252 pages. Available in PDF, EPUB and Kindle. Book excerpt:

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Download or read book Conservation of Books written by Abigail Bainbridge and published by Taylor & Francis. This book was released on 2023-03-27 with total page 735 pages. Available in PDF, EPUB and Kindle. Book excerpt: Conservation of Books is the highly anticipated reference work on global book structures and their conservation, offering the first modern, comprehensive overview on this subject. The volume takes an international approach to its subject. Written by over 70 specialists in conservation and conservation science based in 19 countries, its 26 chapters cover traditional book structures from around the world, the materials from which they are made and how they degrade, and how to preserve and conserve them. It also examines the theoretical underpinnings of conservation: what and how to treat, and the ethical, cultural, and economic implications of treatment. Technical drawings and photographs illustrate the structures and treatments examined throughout the book. Ultimately, readers gain an in-depth understanding of the materiality of books in numerous global contexts and reflect on the practical considerations involved in their analysis and treatment. Conservation of Books is a quintessential reference work for book conservators and anyone working with books, such as collection managers, librarians, curators, dealers, collectors, historians, and related professionals. It is also an indispensable text for students to complement hands-on training in this field.

Download or read book Dark Cognition written by David Vernon and published by Routledge. This book was released on 2020-10-01 with total page 328 pages. Available in PDF, EPUB and Kindle. Book excerpt: *Winner of the Parapsychological Association Book Award 2021* Outlining the scientific evidence behind psi research, Dark Cognition expertly reveals that such anomalous phenomena clearly exist, highlighting that the prevailing view of consciousness, purely as a phenomenon of the brain, fails to account for the empirical findings. David Vernon provides essential coverage of information and evidence for a variety of anomalous psi phenomena, calling for a paradigm shift in how we view consciousness: from seeing it as something solely reliant on the brain to something that is enigmatic, fundamental and all pervasive. The book examines the nature of psi research showing that, despite claims to the contrary, it is clearly a scientific endeavour. It explores evidence from telepathy and scopaesthesia, clairvoyance and remote viewing, precognition, psychokinesis, fields of consciousness, energy healing, out of body experiences, near-death experiences and post death phenomena, showing that not only do these phenomena exist, but that they have significant implications for our understanding of consciousness. Featuring discussion on scientific research methods, reflections on the fields of dark cognition and end-of-chapter questions that encourage critical thinking, this book is an essential text for those interested in parapsychology, consciousness and cognitive psychology.