Download or read book 3D Lung Models for Regenerating Lung Tissue written by Gunilla Westergren-Thorsson and published by Academic Press. This book was released on 2022-08-10 with total page 262 pages. Available in PDF, EPUB and Kindle. Book excerpt: 3D Lung Models for Regenerating Lung Tissue is a comprehensive summary on the current state of art 3D lung models and novel techniques that can be used to regenerate lung tissue. Written by experts in the field, readers can expect to learn more about 3D lung models, novel techniques including bioprinting and advanced imaging techniques, as well as important knowledge about the complexity of the lung and its extracellular matrix composition. Structured into 15 different chapters, the book spans from the original 2D cell culture model on plastic, to advanced 3D lung models such as using human extracellular matrix protein. In addition, the last chapters cover new techniques including 3D printing, bioprinting, and artificial intelligence that can be used to drive the field forward and some future perspectives. This highly topical book with chapters on everything from the complexity of the lung and its microenvironment to cutting-edge 3D lung models, represents an exciting body of work that can be used by researchers during study design, grant writing, as teaching material, or to stay updated with the progression of the field. - A comprehensive summary of advanced 3D lung models written by the experts in the respiratory field - Explore novel techniques that can be used to evaluate and improve 3D lung models, including techniques such as 3D printing, bioprinting, and artificial intelligence - Explains what extracellular matrix is, the complexity of the lung microenvironment, and why this knowledge is important for creating a functional bioartificial lung
Download or read book Innovative 3D models for Understanding Mechanisms underlying Lung Diseases Powerful Tools for Translational Research written by Janette K. Burgess and published by Frontiers Media SA. This book was released on 2024-02-05 with total page 180 pages. Available in PDF, EPUB and Kindle. Book excerpt: The mechanisms underlying acute and chronic lung diseases are complex, reflecting the interplay between multiple cell types, their microenvironment and exogenous challenges. While traditional in vitro cell culture approaches have been instrumental in advancing our knowledge of cellular signalling and function, they typically lack the cell-cell and cell-matrix interactions that define the niche in which lung cell and tissue functions emerge. Implementing in vivo and ex vivo three-dimensional (3D) models more realistically mimicking the in vivo cell-extracellular matrix (ECM) crosstalk should facilitate a considerable leap towards better understanding lung diseases and thus in investigating new pharmacological tools. We are experiencing a revolution in our understanding of the cell types that deposit and remodel ECM in the lung, the dynamic spatial composition of the ECM and cell-cell interactions during disease, and the influence of ECM and cell-derived cues on lung cell biology. In concert, the ex vivo and in vitro models that are being used to examine the role of the 3D microenvironment of the cell in the lung are rapidly developing. The European Respiratory Society has partnered with Frontiers in Pharmacology to launch this research topic in conjunction with the ERS Research Seminar “Innovative 3D models for understanding mechanisms underlying lung diseases: powerful tools for translational research”.
Download or read book Models of Lung Disease written by Joan Gil and published by CRC Press. This book was released on 1990-07-24 with total page 1026 pages. Available in PDF, EPUB and Kindle. Book excerpt: This research-level reference provides a review of the morphological techniques that have become a primary method of anatomical study correlating structure and function in lung physiology and pathology. Detailing the evolution of anatomy as a research discipline, it explores general structural techn
Download or read book Models of Lung Disease written by Joan Gil and published by CRC Press. This book was released on 2020-08-11 with total page 1021 pages. Available in PDF, EPUB and Kindle. Book excerpt: This research-level reference provides a review of the morphological techniques that have become a primary method of anatomical study correlating structure and function in lung physiology and pathology. Detailing the evolution of anatomy as a research discipline, it explores general structural techn
Download or read book Lung The Developmental Morphogenesis Mechanobiology And Stem Cells written by Ahmed El-hashash and published by World Scientific. This book was released on 2019-01-29 with total page 204 pages. Available in PDF, EPUB and Kindle. Book excerpt: With detailed scientific background and up-to-date research, this book examines recent developmental and cell biology, mechanobiology and stem cell biology discoveries to help provide a better understanding of lung development, repair and regeneration.Lung regeneration is an urgent therapeutic priority. The current major challenge is the generation of complex vascularized structures that can ultimately support or replace impaired lung function. Recent discoveries in biomedical engineering are analysed within the structural context of the lung to help provide a better understanding of the innovative solutions that could be used for restoring normal morphogenesis and regeneration of the lung. This also includes insights from basic developmental mechanisms of human lung development through the derivation and identification of stem cells, both from the early embryo as well as from differentiated organs and tissues.Suitable for a wide range of readers, including physicians and surgeons, scientists and researchers, and undergraduate and postgraduate students, this guide is an essential read for those working in the field of lung disease and development.
Download or read book Cellular and Molecular Mechanisms of Lung Regeneration Repair and Fibrosis written by Chunheng Mo and published by Frontiers Media SA. This book was released on 2024-01-23 with total page 123 pages. Available in PDF, EPUB and Kindle. Book excerpt: Organ fibrosis seriously threatens human health. Globally, more than 30% of the diseases that cause disability and death are due to organ fibrosis. However, there have been so far only a few effective treatments for organ fibrosis. Idiopathic pulmonary fibrosis (IPF) is progressive, lethal fibrotic lung disease. Approximately, 10/100,000 people globally suffer from pulmonary fibrosis, and the incidence is on the rise. The median survival for patients is only 3-5 years. Currently there is no effective treatment for lung fibrosis. Therefore, new insights into lung fibrosis and therapeutic strategy should be explored and developed. This Research Topic aims to deepen the understanding and research on the pathogenesis of lung fibrosis to develop effective treatments. Studies have shown that effective lung repair and regeneration are critical biological processes for the restoration of original physiological function of lung after injury. The intrinsic ability of regeneration and repair is often suppressed in lung with chronic injury or the diseased organs, leading to fibrosis and loss of function. Targeting key pathways in the process of lung regeneration can promote the repair of the impaired lung and alleviate fibrosis in animal models. How to induce regeneration and repair of the impaired organ to alleviate fibrosis is a frontier research topic. Hence, this Research Topic focuses on the cellular and molecular mechanisms of lung regeneration, repair, and fibrosis. Moreover, this topic will also focus on the study of lung development to provide new insights into the pathogenesis of lung injury and fibrosis.
Download or read book Determination of Lung Regeneration Using an Ex Vivo Tissue Slice Model written by Franziska Uhl and published by . This book was released on 2015 with total page 117 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Cell Therapy For Lung Disease written by Julia M Polak and published by World Scientific. This book was released on 2010-03-17 with total page 529 pages. Available in PDF, EPUB and Kindle. Book excerpt: The use of stem cells to help with lung regeneration and repair is a novel therapy which could help phase out the need for conventional surgical or pharmacological approaches currently employed to treat diseases of the lung or other organs. The present book explores all avenues of this new form of medical care, moving swiftly, but in depth, from the basic science of lung development, to the analyses of different stem cell types available for regeneration and on to the application of this knowledge base in initial clinical trials.In this volume a stellar group of researchers converge, from different angles, to help towards clarifying the basic mechanisms of lung repair. These range from basic concepts of regeneration and lung development, the analyses of a variety of cell types that may be involved in lung repair, to ways of creating complex lung structures, including artificial and bioartificial lungs. The book offers an insight into repair mechanisms of the diseased lung, the role of specific lung niches and provides information on initial clinical trials as well as the use of stem cells as vehicles for gene therapy. Ingenious technological aspects of assessing stem cell engraftment of stem cell bioprocessing are also included in this volume./a
Download or read book Lung Tissue Engineering written by Patty P. Chen and published by . This book was released on 2004 with total page 77 pages. Available in PDF, EPUB and Kindle. Book excerpt: The focus of this study was to investigate the histology of tissue formed when fetal (16-20 days gestation) and neonatal (2 days old) rat lung cells were grown in a collagen-glycosaminoglycan scaffold. This project employed a collagen-GAG scaffold specifically developed for tissue engineering and investigated the effect of this substratum on the formation of lung histotypic structures in vitro. A cell isolation procedure was developed whereby 19-days gestation type II alveolar cells reaggregated to form alveolar-like structures. The effects of selected scaffold design variables including pore diameter and degradation rate of the substratum on lung tissue regeneration were explored. Lung cell behavior revealed as the cells interact with an analog of the extracellular matrix was also examined. Differences in fetal and neonatal lung cell behavior were identified using histological analysis. Lung cells were obtained from Sprague-Dawley rats after 16-, 19-, and 20-days of gestation and at 2 days after term. These cells were seeded into type I collagen-GAG matrices, sized 8mm in diameter by 2mm in thickness. The medium used, F12K and Ham's nutrient mixture, was supplemented with 10% fetal bovine serum. A seeding density between 1 to 5 million cells per sponge sample was used. Histology studies were performed at termination periods of 2, 14, and 28 days. This paper describes the in vitro formation and long-term maintenance of alveolar-like structures from enzymatically dissociated 19-days gestation fetal rat lung cells cultured on a collagen sponge substrate as a model system for lung tissue engineering.
Download or read book Lung Mechanics written by Jason H. T. Bates and published by Cambridge University Press. This book was released on 2009-07-30 with total page 237 pages. Available in PDF, EPUB and Kindle. Book excerpt: A modern quantitative study of lung mechanics, relating mathematical modeling and engineering principles to lung function, structure, mechanics, and disease.
Download or read book Stem Cell Based Therapy for Lung Disease written by Janette K. Burgess and published by Springer Nature. This book was released on 2019-11-23 with total page 260 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents state-of-the-art pre-clinical models and clinical applications of stem-cell-based therapies applied to different lung diseases, with a special focus on the translation of bench data into clinical studies. Starting with the assumption that abnormal lung tissue repair and regeneration has emerged as the driving force underlying pathogenesis and progression in many lung diseases, it sheds new light on the potential of stem/stromal cells as drivers of repair and sources of reparative factors in the lung. The first part of the book offers an overview of stem cell types and mechanisms involved in lung development, homeostasis, repair and regeneration, and reveals the crucial role of the extracellular matrix within the lung microenvironment. In the second part, leading experts present the latest pre-clinical evidence and clinical applications of stem-cell-based therapies in a wide variety of lung diseases, ranging from COPD and lung fibrosis to other rare lung diseases. The last section discusses stem cell delivery systems and devices, such as aerosolised spray application. This book appeals to pneumologists, stem cell and matrix biologists, as well as bioengeneers with a special interest in regenerative medicine applied to pulmonary diseases.
Download or read book The Lung written by Ahmed El-Hashash and published by . This book was released on 2019 with total page 177 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Decellularization Methods of Tissue and Whole Organ in Tissue Engineering written by Abdol-Mohammad Kajbafzadeh and published by Springer Nature. This book was released on 2021-09-28 with total page 266 pages. Available in PDF, EPUB and Kindle. Book excerpt: This contributed volume is the first of a series that introduces safe, feasible, and practical decellularization and recellularization techniques for tissue and organ reconstruction. We have put special emphasis on the research areas most likely to develop well-engineered scaffolds for tissue and organ engineering, while presenting easily applicable bench-to-bedside approaches highlighting the latest technical innovations in the field. This book includes both a fundamental discussion for a broad understanding of the basis of tissue repair and substitution, as well as chapters written by world renowned specialists from 20 countries providing deeper discussions and analysis of related sub disciplines. Within these pages, the reader will find state-of-the-art protocols and current clinical challenges in cell and tissue biology, including accurate and comprehensive information on extracellular matrices, natural biomaterials, tissue dynamics, morphogenesis, stem cells, cellular fate progressions, cell and tissue properties for in-vitro and in-vivo applications. This comprehensive and carefully organized treatise provides a clear framework for graduate students and postdoctoral researchers new to the field, but also for researchers and practitioners looking to expand their knowledge on tissue and organ reconstruction.
Download or read book Engineering Translational Models of Lung Homeostasis and Disease written by Chelsea M. Magin and published by Springer. This book was released on 2023-07-03 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Cutting-edge engineering approaches towards modelling lung homeostasis and disease have created dynamic new opportunities for interdisciplinary collaboration and unprecedented progress toward understanding and treating lung disease. This text connects established research in lung biology and physiology to innovative engineering strategies for pulmonary modelling. This unique approach aims to encourage and facilitate progress among a greater audience of basic and translational scientists, clinicians, and medical practitioners. Engineering Translational Models of Lung Homeostasis and Disease illustrates the advances in lung tissue characterization, revealing dynamic changes in the structure, mechanics, and composition of the extracellular matrix. This information paves the way for tissue-informed engineering models of pulmonary tissue, improved design of clinical materials, and advances against a variety of common pathologies. Current translational challenges are highlighted, as are engineering opportunities to overcome these barriers. This foundational text holds valuable lessons for researchers and clinicians throughout the fields of engineering, materials science, cell biology, pulmonary medicine, and clinical science. · Each section focuses on a specific region of the lung, presenting either the biological or clinical perspective along with complimentary engineering approaches · Covers the interface of engineering and lung biology · Highlights emerging new models to study lung disease and repair
Download or read book Fibrosis written by Laure Rittié and published by Humana Press. This book was released on 2017-07-27 with total page 531 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume describes state-of-the-art protocols that serve as “recipes” for scientists concentrating on fibrosis research. This book is divided into four sections. Part I focuses on animal models of fibrosis and covers topics such as mimicking fibrosis in the lungs, skin, liver and heart, and generating transgenic mouse models. Part II discusses cell culture systems, where the chapters explore cell types important for the development of fibrosis. Part III looks at the purification, quantification, and analysis of the ECM proteins, and Part IV describes computer-assisted methods such as quantifying fibrillar collagen alignment and exploring the nano-surface of collagen with atomic force microscopy (AFM). Written in the highly successful Methods in Molecular Biology series format, chapters include introductions to their respective topics, lists of the necessary materials and reagents, step-by-step, readily reproducible laboratory protocols, and tips on troubleshooting and avoiding known pitfalls. Cutting-edge and practical, Fibrosis: Methods and Protocols is a valuable resource aimed at outstanding quality and repeatability of research experiments in the fibrosis field.
Download or read book Lung Stem Cells in Development Health and Disease written by Nikolic, Marko Z. and published by European Respiratory Society. This book was released on 2021-04-01 with total page 395 pages. Available in PDF, EPUB and Kindle. Book excerpt: Most organs in the adult human body are able to maintain themselves and undergo repair after injury; these processes are largely dependent on stem cells. In this Monograph, the Guest Editors bring together leading authors in the field to provide information about the different classes of stem cells present both in the developing and adult lung: where they are found, how they function in homeostasis and pathologic conditions, the mechanisms that regulate their behaviour, and how they may be harnessed for therapeutic purposes. The book focuses on stem cells in the mouse and human lung but also includes the ferret as an increasingly important new model organism. Chapters also discuss how lung tissue, including endogenous stem cells, can be generated in vitro from pluripotent stem cell lines. This state-of-the-art collection comprehensively covers one of the most exciting areas of respiratory science
Download or read book Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease written by Venkataramana K Sidhaye and published by Academic Press. This book was released on 2017-03-09 with total page 277 pages. Available in PDF, EPUB and Kindle. Book excerpt: Lung Epithelial Biology in the Pathogenesis of Pulmonary Disease provides a one-stop resource capturing developments in lung epithelial biology related to basic physiology, pathophysiology, and links to human disease. The book provides access to knowledge of molecular and cellular aspects of lung homeostasis and repair, including the molecular basis of lung epithelial intercellular communication and lung epithelial channels and transporters. Also included is coverage of lung epithelial biology as it relates to fluid balance, basic ion/fluid molecular processes, and human disease. Useful to physician and clinical scientists, the contents of this book compile the important and most current findings about the role of epithelial cells in lung disease. Medical and graduate students, postdoctoral and clinical fellows, as well as clinicians interested in the mechanistic basis for lung disease will benefit from the books examination of principles of lung epithelium functions in physiological condition. Provides a single source of information on lung epithelial junctions and transporters Discusses of the role of the epithelium in lung homeostasis and disease Includes capsule summaries of main conclusions as well as highlights of future directions in the field Covers the mechanistic basis for lung disease for a range of audiences
