Download or read book 17 INHERITED THROMBOPHILIA IN PREGNANT PATIENTS A RETROSPECTIVE CLINICAL STUDY written by Octavian Munteanu and published by . This book was released on 2017 with total page pages. Available in PDF, EPUB and Kindle. Book excerpt: BackgroundThrombophilia refers to an abnormality of blood coagulation that increases the risk of thrombosis. Abnormalities of any component of Virchowu2019s triad (circulatory stasis, vascular wall injury or hypercoagulable state) can lead to thrombosis. Most heritable thrombophilias are heterozygous defects. Hereditary thrombophilia arise as a result of over-activity of coagulation factors. The aim of this study was to perform a screening of pregnant women hospitalized in our hospital for hereditary thrombophilia. Material and methodsOur study group included 819 pregnant women. Genetic tests for specific mutations included methylenetetrahydrofolate reductase (MTHFR) gene mutation, factor V Leiden mutation, prothrombin 20210 and factor XIII mutation. Results The incidence of high-risk inherited thrombophilias is low in our study, so the frequency of homozygous factor V Leiden mutation (n=2) is equal with the incidence of homozygous prothrombin G20210A (n=2) mutation- 0.24%. The incidence of heterozygous factor V Leiden was 17,09 % (n=140) , heterozygous prothrombin G20210A mutation was 3.29% (n=27) , homozygosity for the C677T polymorphism of methylene tetrahydrofolate reductase mutations was 5% (n=41) , homozygosity for the A1298C polymorphism is present in 3.17% (n=26) of pregnant women included in our study. Also heterozygous methylene tetrahydrofolate reductase mutations (C677T, A1298C) were present at 48.35%.ConclusionsHereditary thrombophilia is a genetic condition of heterogeneous etiology, determined by genetic mutations that have been found in all factors of coagulation. There is no curative treatment for genetic thrombophilia.Pregnant women that presented risk factors for thrombosis and were diagnosed with high risk hereditary thrombophilia received prophylactic anticoagulant treatment.
Download or read book The Obstetric Hematology Manual written by Sue Pavord and published by Cambridge University Press. This book was released on 2018-02-08 with total page 362 pages. Available in PDF, EPUB and Kindle. Book excerpt: Understand the rapidly growing complexities of obstetric hematology and high-risk pregnancy management, with experts in the field. Now in its second edition, this comprehensive and essential guide focuses on providing the best support for patients and clinical staff, to prevent serious complications in pregnancy and the post-partum period for both mother and baby. Wide-ranging and detailed, the guide offers discussions on basic principles of best care, through to tackling lesser-known hematological conditions, such as cytopenias and hemoglobinopathies. Updated with color illustrations, cutting-edge research, accurate blood film reproductions, and practical case studies, the revised edition places invaluable advice into everyday context. This unique resource is essential reading for trainees and practitioners in obstetrics, anesthesia, and hematology, as well as midwives, nurses, and laboratory staff. Clarifying difficult procedures for disease prevention, the guide ensures safety when the stakes are high. Reflecting current evidence-based guidelines, the updated volume is key to improving pregnancy outcomes worldwide.
Download or read book Pregnancy Thrombophilia written by Petar Ivanov and published by BoD – Books on Demand. This book was released on 2013-09-19 with total page 169 pages. Available in PDF, EPUB and Kindle. Book excerpt: Learn the recent statements concerning the impact and management of mother-fetal thrombophilia, the achievement necessary for gestation complication prevention and realizing a successful pregnancy valuation. Pregnancy Thrombophilia - The Unsuspected Risk encompasses complete many-sides aspects of thrombophilic conditions during pregnancy, including clinical and basic knowledge approach faced to: 1) Obstetricians, IVF involving gynecologists, Internists, and General practitioners, especially skilled in high risk pregnancy assessment will receive up to date evidence for mother thrombophilia testing indications, an incoming pharmacogenetic approach of individualized antithrombotic therapy and thrombotic tendency management in assisted reproductive technics; 2) Physicians, in particular geneticists, biologists and all researchers, who combine the science of the laboratory with teaching practice, will have essential benefits from the chapters of physiology, pathological and molecular basis of maternal/fetus thrombophilia; 3) The mother-health incorporated immunologists will find a new therapeutic approach beyond anticoagulant treatment in pregnancy with autoimmune conditions. Pregnancy Thrombophilia - The Unsuspected Risk gives you a chance to a rapid review of the recent stands, concerning maternal thrombotic state and authoritative and easy to read summary answers in your daily pregnancy follow up practice.
Download or read book Management and Therapy of Early Pregnancy Complications written by Antonio Malvasi and published by Springer. This book was released on 2016-09-14 with total page 367 pages. Available in PDF, EPUB and Kindle. Book excerpt: This richly illustrated book draws on recently acquired knowledge to provide the reader with comprehensive, up-to-date information on the full range of obstetric complications that may be encountered during the first and second trimesters of pregnancy. For all complications, including those potentially involved in malpractice issues, risk factors and clinical presentation are described and detailed guidance is provided on the appropriate treatment. The lucid text is complemented by a wealth of images, diagrams, flow charts, and drawings. The volume has been compiled in collaboration with a large group of gynecologists, obstetricians and internationally renowned scientists to provide an essential guide. Accordingly, this book will be a valuable tool for every obstetrician and gynecologist. Practitioners across the world will be enabled to deepen their knowledge and to refine their approach to complications in daily clinical practice.
Download or read book Maternal Critical Care written by Marc van de Velde and published by Cambridge University Press. This book was released on 2013-07-04 with total page 503 pages. Available in PDF, EPUB and Kindle. Book excerpt: Addresses the challenges of managing critically ill obstetric patients, with chapters authored by intensivists/anesthesiologists and obstetricians/maternal-fetal medicine specialists.
Download or read book Cancer Associated Thrombosis written by Alok A. Khorana and published by CRC Press. This book was released on 2007-09-26 with total page 290 pages. Available in PDF, EPUB and Kindle. Book excerpt: Showcasing the expertise of top-tier specialists who contributed to the newly released guidelines for the care of thrombosis in cancer patients, this exciting guide was written and edited by members of the American Society of Clinical Oncology panel, (ASCO), on the prevention and treatment of cancer-associated thrombosis, among others, and provides
Download or read book Management of Acute Pulmonary Embolism written by Stavros V. Konstantinides and published by Springer Science & Business Media. This book was released on 2007-12-31 with total page 273 pages. Available in PDF, EPUB and Kindle. Book excerpt: This practical volume highlights traditional, novel, and evolving aspects of the diagnosis and treatment of pulmonary embolism (PE). The contributors comprise an international team of experts. Important aspects of diagnosis, risk stratification, and differential treatment of patients with PE are presented in a concise, yet comprehensive manner. Emphasis is placed on specific issues related to PE, including pregnancy, cancer, thrombophilia, and air travel.
Download or read book Respiratory Disease in Pregnancy written by Stephen E. Lapinsky and published by Cambridge University Press. This book was released on 2020-04-09 with total page 261 pages. Available in PDF, EPUB and Kindle. Book excerpt: Respiratory diseases affect a large proportion of the population and can cause complications when associated with pregnancy. Pregnancy induces profound anatomical and functional physiological changes in the mother, and subjects the mother to pregnancy-specific respiratory conditions. Reviewing respiratory conditions both specific and non-specific to pregnancy, the book also addresses related issues such as smoking and mechanical ventilation. Basic concepts for the obstetrician are covered, including patient history, physiology and initial examinations. Topics such as physiological changes during pregnancy and placental gas exchange are discussed for the non-obstetrician. Guidance is practical, covering antenatal and post-partum care, as well as management in the delivery suite. An essential guide to respiratory diseases in pregnancy, this book is indispensable to both obstetricians and non-obstetric physicians managing pregnant patients.
Download or read book Hematological Complications in Obstetrics Pregnancy and Gynecology written by Rodger L. Bick and published by Cambridge University Press. This book was released on 2006-04-20 with total page 589 pages. Available in PDF, EPUB and Kindle. Book excerpt: There are many haematological complications associated with obstetrics, pregnancy and gynaecology, and unfortunately, they often lead to significant morbidity or mortality for both mother and child. As the first comprehensive reference on all aspects of haematological complications of obstetrics, pregnancy and gynaecology this book will be a valuable resource to haematologists, obstetricians, gynaecologists, reproductive medicine specialists, internists, anaesthesiologists and others. The chapters are written by acknowledged experts in the field, and for each condition covered the etiology, pathophysiology, clinical and laboratory diagnosis and management are discussed where appropriate.
Download or read book Subfertility Reproductive Endocrinology and Assisted Reproduction written by Jane A. Stewart and published by Cambridge University Press. This book was released on 2019-06-20 with total page 0 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reproductive medicine and surgery is a major subspecialty in the practice of obstetrics and gynaecology. This textbook provides an introduction to the field of subfertility and reproductive endocrinology, with contributions written by leading experts in the field. This book is based on and compliments a training programme run jointly by the British Fertility Society and the Royal College of Obstetricians and Gynaecologists, making it an indispensable handbook for medical trainees. It will also appeal to clinicians embarking on a career in obstetrics and gynaecology who want an excellent grounding in this area. Specialist nurses will also find the book a valuable resource, and scientists specialising in reproductive medicine and embryology will gain insight into the related clinical areas.
Download or read book Early Pregnancy Loss written by Richard W. Beard and published by Springer Science & Business Media. This book was released on 2012-12-06 with total page 427 pages. Available in PDF, EPUB and Kindle. Book excerpt: The first few months of any pregnancy are of supreme importance to the success of that pregnancy. This statement is so obvious as to be almost a platitude, yet it must be said that no aspect of pregnancy has been more neglected in the human than the first three months. Little is known of the morphological changes that occur at that time and our knowledge of the mechanisms that control this vital stage of pregnancy is almost non-existent. The explanation for this neglect of what is an obvious area for study is the difficulty of obtaining normal material. It is rare to have material to study from a healthy first trimester pregnancy and the study by Hertig and Rock!l) of early conception found by chance in hysterectomy speci mens must be unique. The information that we do have about early pregnancy is mostly gained from animal studies or single miscarriages in humans. Chromosomal defects are common but are not an explanation for the majority of recurrent miscarriages. Obstetricians have hypothesised many causes for this condition and have deve loped numerous metQods for treating it, but the studies have been poorly con trolled so that our understanding of the cause(s) has not advanced. Treatment of women with a history of recurrent miscarriage by paternal leuco cyte infusion (immunotherapy) may be yet another form of treatment that is hailed as a new advance only to be rejected when subject to rigorous testing.
Download or read book Anticoagulation Therapy written by Joe F. Lau and published by Springer. This book was released on 2018-04-16 with total page 464 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book presents the latest evidence and guidelines supporting the use of anticoagulant therapy for various clinical scenarios. The field of anticoagulation therapy is evolving rapidly, particularly since the arrival and widespread adoption of direct oral anticoagulants. Organized in two parts, this book reviews the pharmacologic properties of various anticoagulants and details the clinical applications of anticoagulant therapy. Drugs such as warfarin and unfractionated heparin, as well as parenteral and direct oral anticoagulants are discussed in terms of their pharmacokinetics, drug-disease interactions, dosing strategies, and risk considerations. Clinical applications of anticoagulant therapy in disorders such as acute coronary syndromes, atrial fibrillation, and thrombophilia and in special populations such as pregnant women, the elderly, and in the patient with cancer are highlighted. Clinical vignettes, algorithms, clinical pearls, and self-assessment questions are integrated throughout the book. Featuring contributions from authorities in the field, Anticoagulation Therapy is an essential resource for cardiologists, vascular medicine specialists, hematologists, internists, and all other healthcare professionals who prescribe anticoagulants.
Download or read book Chesley s Hypertensive Disorders in Pregnancy written by Robert N. Taylor and published by Elsevier. This book was released on 2014-08-28 with total page 500 pages. Available in PDF, EPUB and Kindle. Book excerpt: Chesley’s Hypertensive Disorders in Pregnancy continues its tradition as one of the beacons to guide the field of preeclampsia research, recognized for its uniqueness and utility. Hypertensive disorders remain one the major causes of maternal and fetal morbidity and death. It is also a leading cause of preterm birth now known to be a risk factor in remote cardiovascular disease. Despite this the hypertensive disorders remain marginally studied and management is often controversial. The fourth edition of Chesley’s Hypertensive Disorders in Pregnancy focuses on prediction, prevention, and management for clinicians, and is an essential reference text for clinical and basic investigators alike. Differing from other texts devoted to preeclampsia, it covers the whole gamut of high blood pressure, and not just preeclampsia. Features new chapters focusing on recent discoveries in areas such as fetal programming, genomics/proteomics, and angiogenesis Includes extensive updates to chapters on epidemiology, etiological considerations, pathophysiology, prediction, prevention, and management Discusses the emerging roles of metabolic syndrome and obesity and the increasing incidence of preeclampsia Each section overseen by one of the editors; each chapter co-authored by one of the editors, ensuring coherence throughout book
Download or read book Cerebral Venous Thrombosis written by Marie-Germaine Bousser and published by Bailliere Tindall. This book was released on 1997 with total page 200 pages. Available in PDF, EPUB and Kindle. Book excerpt: Illustrated with recent imaging techniques, this text provides comprehensive coverage of intracranial venous thrombosis mechanisms, aetiology, clinical investigation, diagnosis and management.
Download or read book Prescribing in Pregnancy written by Peter C. Rubin and published by John Wiley & Sons. This book was released on 2008-04-30 with total page 256 pages. Available in PDF, EPUB and Kindle. Book excerpt: This thoroughly revised edition of Prescribing in Pregnancy is a practical and authoritative guide for all doctors who prescribe for pregnant women. Covering both the prescribing of drugs for common conditions in pregnant women and the effect of different drugs on pregnancy, the fourth edition now also features: strengthened evidence for the prescribing regimens updated prescribing information throughout a new user-friendly design Written by leading specialists, Prescribing in Pregnancy covers the common medical problems encountered in pregnancy, and includes information on travel medicine, breast feeding and the management of drug and alcohol abuse. The fourth edition of this comprehensive and relevant book is an invaluable reference for the busy doctor, on the wards and in general practice.
Download or read book Hemostasis and Thrombosis in Obstetrics and Gynecology written by Michael J. Paidas and published by John Wiley & Sons. This book was released on 2011-07-05 with total page 232 pages. Available in PDF, EPUB and Kindle. Book excerpt: Reproductive hemostasis: A global approach to a global challenge A hemostatic change in women through their reproductive lifetime is emerging as an issue of global importance. No wonder, as obstetric hemorrhage remains a major cause of maternal mortality in both developed and developing countries. Thrombophilias and pulmonary embolisms are a threat to maternal and fetal well-being. Hemostasis and Thrombosis in Obstetrics & Gynecology provides a framework for assessing and managing hemostatic disorders in women. Written by an international team, it provides globally applicable guidelines for obstetric hematology. The practical approach to clinical management includes: Hematologic changes in pregnancy Red cell disorders Platelet disorders Inherited and acquired thrombophilia Inherited bleeding disorders Postpartum hemorrhage Blood and bleeding disorders in women can be managed by obstetrician-gynecologists or hematologists, separately or together. Hemostasis and Thrombosis in Obstetrics & Gynecology provides specialists from both disciplines with the information necessary to manage their patients effectively.
Download or read book Myeloproliferative Neoplasms written by Tiziano Barbui and published by Springer Science & Business Media. This book was released on 2012-02-03 with total page 235 pages. Available in PDF, EPUB and Kindle. Book excerpt: This book focuses on three of the main categories of myeloproliferative neoplasm: polycythemia vera, essential thrombocythemia, and primary myelofibrosis. Relevant laboratory and clinical advances are comprehensively covered, and great emphasis is placed on the practical issues that challenge physicians in their daily practice. The main topics considered thus include contemporary diagnostic approaches, the value and limitations of mutation screening for diagnostic and prognostic purposes, risk stratification in terms of both survival and other disease complications such as leukemic transformation and thrombosis, and modern therapeutic strategies, including conventional drugs, allogeneic stem cell transplantation, and experimental drugs still under study. The reader will find Critical Concepts and Management Recommendations in Myeloproliferative Neoplasms to be an invaluable and up-to-date source of information from leading authorities in the field.
