Download or read book Microsomes and Drug Oxidations written by Volker Ullrich and published by Elsevier. This book was released on 2013-10-22 with total page 805 pages. Available in PDF, EPUB and Kindle. Book excerpt: Microsomes and Drug Oxidations is a record of the proceedings of the Third International Symposium on Microsomes and Drug Oxidations, held in Berlin, Germany in July 1976. The compendium provides an overview of knowledge on the oxidative metabolism of drugs, carcinogens, and various other environmental chemicals. Topics discussed include lipid structure of liver microsomal membranes; interactions between cytochrome p-450 and nadphcytochrome p-450 reductase in the microsomal membrane; impact of drug monoxygenases in clinical pharmacology; and the manner in which oxygen participates in mixed-function oxidation reactions. Pharmacologists, toxicologists, biochemists, and researchers in the pharmaceutical industry will find the book highly insightful.
Download or read book Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on 1983 with total page 1442 pages. Available in PDF, EPUB and Kindle. Book excerpt: First multi-year cumulation covers six years: 1965-70.
Download or read book Cytochrome P450 written by Paul R. Ortiz de Montellano and published by Springer Science & Business Media. This book was released on 2013-11-11 with total page 655 pages. Available in PDF, EPUB and Kindle. Book excerpt: In the ten years that have elapsed since the first edition of this book went to press, the cytochrome P450 field has completed the transition to a discipline in which structure and mechanism, even regulation and biological function, are dealt with in molecular terms. The twin forces that have propelled this remarkable progress have been the widespread adoption of molecular biological approaches and the successful application of modem structural techniques. Only a few P450 primary sequences were available in 1985, whereas hundreds of P450 sequences are now available. Site-specific mutagenesis was then mostly a proverbial gleam in the eye of the P450 community, but it is now a standard technique in the research repertoire. The first crystal structure of a cytochrome P450 enzyme had just been solved in 1985 and appeared on the cover of the first edition. Today, the high-reso lution crystal structures of four soluble bacterial P450 enzymes are available and the race is on to develop approaches that will permit us to determine the structures of the membrane-bound forms of the enzyme. The past ten years has seen phenomenal progress let us hope that the next ten will prove equally exciting. The book is informally divided into four sections. In order to hold the book close to the advancing front of research, some of the chapter topics from the first edition have been dropped to make room for new or expanded topics.
Download or read book Cytochromes written by David F.V. Lewis and published by Taylor & Francis. This book was released on 2003-09 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Guide to Cytochromes written by David F.V. Lewis and published by CRC Press. This book was released on 1996-07-03 with total page 344 pages. Available in PDF, EPUB and Kindle. Book excerpt: This guide to the structure, function and mechanism of the cytochromes P450 focuses on the role of P450s in xenobiotic metabolism and toxicity. Colour illustrations show how modelling of P450s can rationalize their substrate specificity for the metabolism of both endogenous and exogenous chemicals.
Download or read book Index of Conference Proceedings written by and published by . This book was released on 1996 with total page 856 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Pharmacokinetics Metabolism and Pharmaceutics of Drugs of Abuse written by and published by . This book was released on 1997 with total page 336 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Five Lipoxygenase Products in Asthma written by Jeffrey Drazen and published by CRC Press. This book was released on 2016-04-19 with total page 520 pages. Available in PDF, EPUB and Kindle. Book excerpt: Five-Lipoxygenase Products in Asthma offers an authoritative examination of the biochemistry, basic pharmacology, and clinical pharmacology of the leukotrienes with special emphasis on their role in asthma. A critical reference for every asthma researcher and clinician, Five-Lipoxygenase Products in Asthma highlights agents and products
Download or read book Registry of Toxic Effects of Chemical Substances written by National Institute for Occupational Safety and Health and published by . This book was released on 1985 with total page 576 pages. Available in PDF, EPUB and Kindle. Book excerpt: "This compilation will provide ready reference for potential toxicity of chemicals found in the workplace, and should be useful to occupational health physicians, industrial hygienists, toxicologists, and researchers." Alphabetical arrangement by substances. Entries include such details as molecular weight, Wiswesser Line Notation, synonyms, and reference from which data about toxicity derived. Miscellaneous appendixes, including one titled Aquatic toxicity. Bibliographic references.
Download or read book Environmental Health Perspectives written by and published by . This book was released on 2000 with total page 584 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book National Library of Medicine Current Catalog written by National Library of Medicine (U.S.) and published by . This book was released on with total page 1000 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Comprehensive Toxicology written by Charlene A. McQueen and published by Pergamon. This book was released on 1997-07-01 with total page 558 pages. Available in PDF, EPUB and Kindle. Book excerpt: Comprehensive Toxicology - the first comprehensive reference work in toxicology, is an in-depth, state-of-the-art review of toxicology of unrivalled quality. It is designed to encompass investigation from a molecular level to the intact organism. Presented in a 13-volume printed form.
Download or read book Microscale Testing in Aquatic Toxicology written by Peter G. Wells and published by CRC Press. This book was released on 2018-05-04 with total page 716 pages. Available in PDF, EPUB and Kindle. Book excerpt: Bioassays are among the ecotoxicologist's most effective weapons in the evaluation of water quality and the assessment of ecological impacts of effluents, chemicals, discharges, and emissions on the aquatic environment. Information on these assessment aids is needed throughout the international scientific and environmental management community. This comprehensive reference provides an excellent overview of the small-scale aquatic bioassay techniques and applications currently in use around the world. This special volume is the result of several years of collaboration between Environment Canada and Fisheries and Oceans Canada. Internationally recognized research scientists at many institutions have contributed to this state-of-the-art examination of the exciting, environmentally important field of microscale testing in aquatic toxicology. Microscale Testing in Aquatic Toxicology contains over forty chapters covering relevant principles, new techniques and recent advancements, and applications in scientific research, environmental management, academia, and the private sector.
Download or read book Index of Conference Proceedings Received written by British Library. Document Supply Centre and published by . This book was released on 1987 with total page 792 pages. Available in PDF, EPUB and Kindle. Book excerpt:
Download or read book Drug Abuse in the Decade of the Brain written by Gabriel G. Nahas and published by IOS Press. This book was released on 1997 with total page 312 pages. Available in PDF, EPUB and Kindle. Book excerpt: Life scientists have declared the 1990s to be the "Decade of the Brain." Undoubtedly the most important organ, the brain is perhaps the least understood. Until recently, the proper methodology for exploring the basic functions of the brain were not available. However, the new era of computer technology brain imaging and molecular biology have given scientists the tools for studying previously hidden mechanisms of the brain which control thinking, emotions, and behavior. Along with this new knowledge, scientists have observed that drugs of abuse can alter these same brain functions in a profound and persistent manner. Drugs of abuse are widely used substances that differ in chemical nature but have a common property-creating dependence. Dependence is characterized by a stereotypical pattern of behavior oriented toward the search, acquisition, and ingestion of drugs of abuse with such frequency and in such quantity as to be harmful. This behavior is beyond the control of reason and will. Studies conducted during the "decade of the brain" or before, show that the clinically observed, dependent behavior induced by drugs of abuse result from neurophysiological and chemical alterations of complex brain mechanisms. These mechanisms involve the production and turnover of the brain neurotransmitters that carry information in the brain neurocircuitry, changes in brain metabolism and circulation, and alterations in the expression of DNA which programs the functions or the neuronal cell. This book describes a number of newly discovered basic brain mechanisms and the alterations caused by drugs of abuse. Contributions by top researchers in fields of radian biology, biochemistry, genetics, and pharmacology examine the new technological improvements for the measurement of brain function, metabolism, blood flow and drug elimination and report changes in brain biochemistry, including DNA expression, as they occur during drug abuse. Physicians and health professionals will benefit from a better understanding of the effects of drugs on the brain which will lead to more effective interventions for prevention and treatment. Highlights include: New knowledge about the brain New methods of investigation Opiates and the brain Marijuana and the brain Cocaine and the brain This book will be of interest to health professionals and program administrators involved in the education and treatment of substance abuse disorders, as well as physicians, nurses, psychiatric social workers, neuroscientists, and pharmacologists.
Download or read book Pharmacological Sciences Perspectives for Research and Therapy in the Late 1990s written by A. Claudio Cuello and published by Birkhäuser. This book was released on 2012-12-06 with total page 702 pages. Available in PDF, EPUB and Kindle. Book excerpt: This volume arose from the scientific program of the XIIth International Congress of Pharmacology, held in Montreal, Canada, July 24-29, 1994. The scientific program included plenary lectures and symposia, in addition to poster presentations and colloquia. The abstracts of the Congress presentations were published as .supplement 1 of volume 72 by the Cana dian Journal of Physiology & Pharmacology. The Congress organizers sought a more expansive treatment of the Congress proceedings and appointed Dr. A. Claudio Cuello to coordinate preparation of the present volume; Dr. Brian Collier was chair of the scientific program committee and, thus, also collaborated on this work. The objective that we pursued was to produce a volume of reasonable size which would feature all of the plenary lectures and symposia from those authors who agreed to participate. To this end, we solicited mini reviews from plenary lecturers and asked symposia organizers to coordi nate a single short-review covering the individual topics within their event. Those who accepted this challenge are evident in this volume. We express our gratitude to these authors for doing so, and for exercising considerable ingenuity in completing their task within a reasonable time.
Download or read book NIDA Research Monograph written by and published by . This book was released on 1976 with total page 332 pages. Available in PDF, EPUB and Kindle. Book excerpt:
